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10.1016/j.intimp.2014.06.013 http://scihub22266oqcxt.onion/10.1016/j.intimp.2014.06.013 24968347!7106131!24968347     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Immunopharmacol 2014 ; 22 (1): 1-8 Nephropedia Template TP {{tp|p=24968347|t=2014. N-acetyl-l-cystine (NAC) protects against H9N2 swine influenza virus-induced acute lung injury |pdf=|usr=}}{{24968347}} gab.com Text N-acetyl-l-cystine (NAC) protects against H9N2 swine influenza virus-induced acute lung injury JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24968347 #FOAvip The antioxidant N-acetyl-l-cysteine (NAC) had been shown to inhibit replication of seasonal human influenza A viruses. Here, the effects of NAC on H9N2 swine influenza virus-induced acute lung injury (ALI) were investigated in mice. BALB/c mice were inoculated intranasally with 10(7) 50% tissue culture infective doses (TCID(50)) of A/swine/HeBei/012/2008/(H9N2) viruses with or without NAC treatments to induce ALI model. The result showed that pulmonary inflammation, pulmonary edema, MPO activity, total cells, neutrophils, macrophages, TNF-alpha, IL-6, IL-1beta and CXCL-10 in BALF were attenuated by NAC. Moreover, our data showed that NAC significantly inhibited the levels of TLR4 protein and TLR4 mRNA in the lungs. Pharmacological inhibitors of TLR4 (E5564) exerted similar effects like those determined for NAC in H9N2 swine influenza virus-infected mice. These results suggest that antioxidants like NAC represent a potential additional treatment option that could be considered in the case of an influenza A virus pandemic. Twit Text FOAVip N-acetyl-l-cystine (NAC) protects against H9N2 swine influenza virus-induced acute lung injury ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24968347 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24968347 #FOAvip English Wikipedia <ref>{{Cite pmid|24968347}}</ref> N-acetyl-l-cystine (NAC) protects against H9N2 swine influenza virus-induced acute lung injury #MMPMID24968347 Zhang RH; Li CH; Wang CL; Xu MJ; Xu T; Wei D; Liu BJ; Wang GH; Tian SF Int Immunopharmacol 2014[Sep]; 22 (1): 1-8 PMID24968347show ga The antioxidant N-acetyl-l-cysteine (NAC) had been shown to inhibit replication of seasonal human influenza A viruses. Here, the effects of NAC on H9N2 swine influenza virus-induced acute lung injury (ALI) were investigated in mice. BALB/c mice were inoculated intranasally with 10(7) 50% tissue culture infective doses (TCID(50)) of A/swine/HeBei/012/2008/(H9N2) viruses with or without NAC treatments to induce ALI model. The result showed that pulmonary inflammation, pulmonary edema, MPO activity, total cells, neutrophils, macrophages, TNF-alpha, IL-6, IL-1beta and CXCL-10 in BALF were attenuated by NAC. Moreover, our data showed that NAC significantly inhibited the levels of TLR4 protein and TLR4 mRNA in the lungs. Pharmacological inhibitors of TLR4 (E5564) exerted similar effects like those determined for NAC in H9N2 swine influenza virus-infected mice. These results suggest that antioxidants like NAC represent a potential additional treatment option that could be considered in the case of an influenza A virus pandemic. |Acetylcysteine/*administration & dosage[MESH] |Acute Lung Injury/etiology/*immunology/prevention & control[MESH] |Animals[MESH] |Antioxidants/*administration & dosage[MESH] |Cytokines/metabolism[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Inflammation Mediators/metabolism[MESH] |Influenza A Virus, H9N2 Subtype/drug effects/*physiology[MESH] |Influenza, Human/drug therapy/*immunology[MESH] |Lipid A/administration & dosage/analogs & derivatives/pharmacology[MESH] |Lung/drug effects/*immunology/virology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Orthomyxoviridae Infections/complications/drug therapy/*immunology[MESH] |Peroxidase/metabolism[MESH] |Swine[MESH] |Toll-Like Receptor 4/antagonists & inhibitors/genetics/metabolism[MESH]N-acetyl-l-cystine (NAC) protects against H9N2 swine influenza virus-i(epmc).pdf DeepDyve Pubget Overpricing