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10.1186/2051-5960-2-67 http://scihub22266oqcxt.onion/10.1186/2051-5960-2-67 24938728/?report=reader!4229875!24938728     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Neuropathol+Commun 2014 ; 2 (ä): 67 Nephropedia Template TP {{tp|p=24938728|t=2014. Selective vulnerability of the cerebral vasculature to blast injury in a rat model of mild traumatic brain injury |pdf=|usr=}}{{24938728}} gab.com Text Selective vulnerability of the cerebral vasculature to blast injury in a rat model of mild traumatic brain injury JO: Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=24938728 #FOAvip BACKGROUND: Blast-related traumatic brain injury (TBI) is a common cause of injury in the military operations in Iraq and Afghanistan. How the primary blast wave affects the brain is not well understood. The aim of the present study was to examine whether blast exposure affects the cerebral vasculature in a rodent model. We analyzed the brains of rats exposed to single or multiple (three) 74.5 kPa blast exposures, conditions that mimic a mild TBI. Rats were sacrificed 24 hours or between 6 and 10 months after exposure. Blast-induced cerebral vascular pathology was examined by a combination of light microscopy, immunohistochemistry, and electron microscopy. RESULTS: We describe a selective vascular pathology that is present acutely at 24 hours after injury. The vascular pathology is found at the margins of focal shear-related injuries that, as we previously showed, typically follow the patterns of penetrating cortical vessels. However, changes in the microvasculature extend beyond the margins of such lesions. Electron microscopy revealed that microvascular pathology is found in regions of the brain with an otherwise normal neuropil. This initial injury leads to chronic changes in the microvasculature that are still evident many months after the initial blast exposure. CONCLUSIONS: These studies suggest that vascular pathology may be a central mechanism in the induction of chronic blast-related injury. Twit Text FOAVip Selective vulnerability of the cerebral vasculature to blast injury in a rat model of mild traumatic brain injury ????Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=24938728 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24938728 #FOAvip English Wikipedia <ref>{{Cite pmid|24938728}}</ref> Selective vulnerability of the cerebral vasculature to blast injury in a rat model of mild traumatic brain injury #MMPMID24938728 Gama Sosa MA; De Gasperi R; Janssen PL; Yuk FJ; Anazodo PC; Pricop PE; Paulino AJ; Wicinski B; Shaughness MC; Maudlin-Jeronimo E; Hall AA; Dickstein DL; McCarron RM; Chavko M; Hof PR; Ahlers ST; Elder GA Acta Neuropathol Commun 2014[Jun]; 2 (ä): 67 PMID24938728show ga BACKGROUND: Blast-related traumatic brain injury (TBI) is a common cause of injury in the military operations in Iraq and Afghanistan. How the primary blast wave affects the brain is not well understood. The aim of the present study was to examine whether blast exposure affects the cerebral vasculature in a rodent model. We analyzed the brains of rats exposed to single or multiple (three) 74.5 kPa blast exposures, conditions that mimic a mild TBI. Rats were sacrificed 24 hours or between 6 and 10 months after exposure. Blast-induced cerebral vascular pathology was examined by a combination of light microscopy, immunohistochemistry, and electron microscopy. RESULTS: We describe a selective vascular pathology that is present acutely at 24 hours after injury. The vascular pathology is found at the margins of focal shear-related injuries that, as we previously showed, typically follow the patterns of penetrating cortical vessels. However, changes in the microvasculature extend beyond the margins of such lesions. Electron microscopy revealed that microvascular pathology is found in regions of the brain with an otherwise normal neuropil. This initial injury leads to chronic changes in the microvasculature that are still evident many months after the initial blast exposure. CONCLUSIONS: These studies suggest that vascular pathology may be a central mechanism in the induction of chronic blast-related injury. |Animals[MESH] |Blast Injuries/*complications[MESH] |Brain Injuries/*etiology/*pathology[MESH] |Cerebral Cortex/metabolism/*pathology/ultrastructure[MESH] |Cerebral Hemorrhage/*etiology/pathology[MESH] |Disease Models, Animal[MESH] |Glial Fibrillary Acidic Protein/metabolism[MESH] |Gliosis/etiology[MESH] |Male[MESH] |Microscopy, Electron[MESH] |Microvessels/metabolism/pathology/ultrastructure[MESH] |Rats[MESH] |Rats, Long-Evans[MESH] |Time Factors[MESH]Selective vulnerability of the cerebral vasculature to blast injury in(epmc).pdf DeepDyve Pubget Overpricing