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10.7314/apjcp.2014.15.9.3955 http://scihub22266oqcxt.onion/10.7314/apjcp.2014.15.9.3955 24935580!ä!24935580 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Asian+Pac+J+Cancer+Prev 2014 ; 15 (9): 3955-8 Nephropedia Template TP {{tp|p=24935580|t=2014. Overexpression of TRPM7 is associated with poor prognosis in human ovarian carcinoma |pdf=|usr=}}{{24935580}} gab.com Text Overexpression of TRPM7 is associated with poor prognosis in human ovarian carcinoma JO: Asian Pac J Cancer Prev http://www.kidney.de/pget.php?&tw=1&pmid=24935580 #FOAvip BACKGROUND: The melastatin-related transient receptor potential 7 channel (TRPM7) is a nonselective cation channel that has been shown to promote tumor metastasis and progression. In this study, we determined the expression of TRPM7 in ovarian carcinomas and investigated its possible prognostic value. MATERIALS AND METHODS: Samples were collected from 138 patients with ovarian cancer. Expression of TRPM7 was assessed by real-time PCR and immunohistochemistry, expressed with reference to an established scoring system and related to clinical pathological factors. Kaplan-Meier survival analysis was applied to estimate disease-free survival (DFS) and overall survival (OS). Univariate and multivariate cox regression analyses were performed to correlate TRPM7 expression levels with DFS and OS. RESULTS: TRPM7 was highly expressed in ovarian carcinoma and significantly associated with decreased disease-free survival (DFS: median 20 months vs. 42 months, P=0.0002) and overall survival (OS: median 27 months vs. 46 months, P<0.001). CONCLUSION: Overexpression of TRPM7 expression is significantly associated with poor prognosis in patients with ovarian cancer. Twit Text FOAVip Overexpression of TRPM7 is associated with poor prognosis in human ovarian carcinoma ????Asian Pac J Cancer Prev http://www.kidney.de/pget.php?&tw=1&pmid=24935580 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24935580 #FOAvip English Wikipedia <ref>{{Cite pmid|24935580}}</ref> Overexpression of TRPM7 is associated with poor prognosis in human ovarian carcinoma #MMPMID24935580 Wang J; Xiao L; Luo CH; Zhou H; Hu J; Tang YX; Fang KN; Zhang Y Asian Pac J Cancer Prev 2014[]; 15 (9): 3955-8 PMID24935580show ga BACKGROUND: The melastatin-related transient receptor potential 7 channel (TRPM7) is a nonselective cation channel that has been shown to promote tumor metastasis and progression. In this study, we determined the expression of TRPM7 in ovarian carcinomas and investigated its possible prognostic value. MATERIALS AND METHODS: Samples were collected from 138 patients with ovarian cancer. Expression of TRPM7 was assessed by real-time PCR and immunohistochemistry, expressed with reference to an established scoring system and related to clinical pathological factors. Kaplan-Meier survival analysis was applied to estimate disease-free survival (DFS) and overall survival (OS). Univariate and multivariate cox regression analyses were performed to correlate TRPM7 expression levels with DFS and OS. RESULTS: TRPM7 was highly expressed in ovarian carcinoma and significantly associated with decreased disease-free survival (DFS: median 20 months vs. 42 months, P=0.0002) and overall survival (OS: median 27 months vs. 46 months, P<0.001). CONCLUSION: Overexpression of TRPM7 expression is significantly associated with poor prognosis in patients with ovarian cancer. |Biomarkers, Tumor/biosynthesis/genetics[MESH] |Disease-Free Survival[MESH] |Female[MESH] |Gene Expression Regulation, Neoplastic[MESH] |Humans[MESH] |Middle Aged[MESH] |Neoplasm Metastasis/pathology[MESH] |Neoplasm Staging[MESH] |Ovarian Neoplasms/*mortality/*pathology[MESH] |Proportional Hazards Models[MESH] |Protein Serine-Threonine Kinases/*biosynthesis/genetics[MESH] |RNA, Messenger/biosynthesis[MESH] |Real-Time Polymerase Chain Reaction[MESH]Overexpression of TRPM7 is associated with poor prognosis in human ova(epmc).pdf DeepDyve Pubget Overpricing