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10.1111/pin.12159 http://scihub22266oqcxt.onion/10.1111/pin.12159 24888773!7167665!24888773     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pathol+Int 2014 ; 64 (5): 199-208 Nephropedia Template TP {{tp|p=24888773|t=2014. Mice lacking alpha1,3-fucosyltransferase 9 exhibit modulation of in vivo immune responses against pathogens |pdf=|usr=}}{{24888773}} gab.com Text Mice lacking alpha1,3-fucosyltransferase 9 exhibit modulation of in vivo immune responses against pathogens JO: Pathol Int http://www.kidney.de/pget.php?&tw=1&pmid=24888773 #FOAvip Carbohydrate structures, including Lewis X (Le(x)), which is not synthesized in mutant mice that lack alpha1,3-fucosyltransferase 9 (Fut9(-/-)), are involved in cell-cell recognition and inflammation. However, immunological alteration in Fut9(-/-) mice has not been studied. Thus, the inflammatory response of Fut9(-/-) mice was examined using the highly neurovirulent mouse hepatitis virus (MHV) JHMV srr7 strain. Pathological study revealed that inflammation induced in the brains of Fut9(-/-) mice after infection was more extensive compared with that of wild-type mice, although viral titers obtained from the brains of mutant mice were lower than those of wild-type mice. Furthermore, the reduction in cell numbers in the spleens of wild-type mice after infection was not observed in the infected Fut9(-/-) mice. Although there were no clear differences in the levels of cytokines examined in the brains between Fut9(-/-) and wild-type mice except for interferon-beta expression, some of those in the spleens, including interferon-gamma, interleukin-6, and monocyte chemoattractant protein 1, showed higher levels in Fut9(-/-) than in wild-type mice. Furthermore, Fut9(-/-) mice were refractory to the in vivo inoculation of endotoxin (LPS) compared with wild-type mice. These results indicate that Le(x) structures are involved in host responses against viral or bacterial challenges. Twit Text FOAVip Mice lacking alpha1,3-fucosyltransferase 9 exhibit modulation of in vivo immune responses against pathogens ????Pathol Int http://www.kidney.de/pget.php?&tw=1&pmid=24888773 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24888773 #FOAvip English Wikipedia <ref>{{Cite pmid|24888773}}</ref> Mice lacking alpha1,3-fucosyltransferase 9 exhibit modulation of in vivo immune responses against pathogens #MMPMID24888773 Kashiwazaki H; Kakizaki M; Ikehara Y; Togayachi A; Narimatsu H; Watanabe R Pathol Int 2014[May]; 64 (5): 199-208 PMID24888773show ga Carbohydrate structures, including Lewis X (Le(x)), which is not synthesized in mutant mice that lack alpha1,3-fucosyltransferase 9 (Fut9(-/-)), are involved in cell-cell recognition and inflammation. However, immunological alteration in Fut9(-/-) mice has not been studied. Thus, the inflammatory response of Fut9(-/-) mice was examined using the highly neurovirulent mouse hepatitis virus (MHV) JHMV srr7 strain. Pathological study revealed that inflammation induced in the brains of Fut9(-/-) mice after infection was more extensive compared with that of wild-type mice, although viral titers obtained from the brains of mutant mice were lower than those of wild-type mice. Furthermore, the reduction in cell numbers in the spleens of wild-type mice after infection was not observed in the infected Fut9(-/-) mice. Although there were no clear differences in the levels of cytokines examined in the brains between Fut9(-/-) and wild-type mice except for interferon-beta expression, some of those in the spleens, including interferon-gamma, interleukin-6, and monocyte chemoattractant protein 1, showed higher levels in Fut9(-/-) than in wild-type mice. Furthermore, Fut9(-/-) mice were refractory to the in vivo inoculation of endotoxin (LPS) compared with wild-type mice. These results indicate that Le(x) structures are involved in host responses against viral or bacterial challenges. |Animals[MESH] |Brain/pathology/virology[MESH] |Cell Count[MESH] |Coronavirus Infections/immunology/pathology/prevention & control[MESH] |Cytokines/metabolism[MESH] |Disease Models, Animal[MESH] |Fucosyltransferases/*deficiency/genetics/physiology[MESH] |Immunity, Innate/genetics/*immunology/physiology[MESH] |Lipopolysaccharides/*immunology[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Mice, Mutant Strains[MESH] |Murine hepatitis virus/*immunology/isolation & purification[MESH]Mice lacking alpha1,3-fucosyltransferase 9 exhibit modulation of in vi(epmc).pdf DeepDyve Pubget Overpricing