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10.1016/j.cell.2014.04.007 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.04.007 24855941!ä!24855941 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24855941&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cell 2014 ; 157 (5): 1013-22 Nephropedia Template TP {{tp|p=24855941|t=2014. Mechanisms and functions of inflammasomes |pdf=|usr=}}{{24855941}} gab.com Text Mechanisms and functions of inflammasomes JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=24855941 #FOAvip Recent studies have offered a glimpse into the sophisticated mechanisms by which inflammasomes respond to danger and promote secretion of interleukin (IL)-1beta and IL-18. Activation of caspases 1 and 11 in canonical and noncanonical inflammasomes, respectively, also protects against infection by triggering pyroptosis, a proinflammatory and lytic mode of cell death. The therapeutic potential of inhibiting these proinflammatory caspases in infectious and autoimmune diseases is raised by the successful deployment of anti-IL-1 therapies to control autoinflammatory diseases associated with aberrant inflammasome signaling. This Review summarizes recent insights into inflammasome biology and discusses the questions that remain in the field. Twit Text FOAVip Mechanisms and functions of inflammasomes ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=24855941 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24855941 #FOAvip English Wikipedia <ref>{{Cite pmid|24855941}}</ref> Mechanisms and functions of inflammasomes #MMPMID24855941 Lamkanfi M; Dixit VM Cell 2014[May]; 157 (5): 1013-22 PMID24855941show ga Recent studies have offered a glimpse into the sophisticated mechanisms by which inflammasomes respond to danger and promote secretion of interleukin (IL)-1beta and IL-18. Activation of caspases 1 and 11 in canonical and noncanonical inflammasomes, respectively, also protects against infection by triggering pyroptosis, a proinflammatory and lytic mode of cell death. The therapeutic potential of inhibiting these proinflammatory caspases in infectious and autoimmune diseases is raised by the successful deployment of anti-IL-1 therapies to control autoinflammatory diseases associated with aberrant inflammasome signaling. This Review summarizes recent insights into inflammasome biology and discusses the questions that remain in the field. |Adaptor Proteins, Signal Transducing/metabolism[MESH] |Animals[MESH] |Autoimmune Diseases/immunology/pathology/therapy[MESH] |Cell Death[MESH] |Humans[MESH] |Infections/immunology/microbiology[MESH] |Inflammasomes/*immunology/metabolism[MESH] |Inflammation/immunology/pathology/therapy[MESH] |Interleukin-1/immunology[MESH]Mechanisms and functions of inflammasomes (epmc).pdf DeepDyve Pubget Overpricing