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suck abstract from ncbi


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pmid24817288      Eur+Rev+Med+Pharmacol+Sci 2014 ; 18 (8): 1151-7
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  • Influence of lactuside B on the expression of AQP4 and TRPM7 mRNAs in the cerebral cortex after cerebral ischemia injury #MMPMID24817288
  • Zhan HQ; Li PF; Li SY; Yan FL; Yang J; Liu RL; Zhang HF
  • Eur Rev Med Pharmacol Sci 2014[]; 18 (8): 1151-7 PMID24817288show ga
  • AIM: This study aimed to determine the effect of Lactuside B isolated from Pterocypsela alata on the expression of AQP4 and TRPM7 mRNAs after cerebral ischemic injury. MATERIALS AND METHODS: Brain ischemia injury was established by occluding the MCA (middle cerebral artery) for 2 h, followed by reperfusion in rats. The neurologic deficit scores were used to determine the success of the model. All drugs were intraperitoneally administered once a day (5 ml/kg). Eight animals from each group were investigated for the Na+ level, and the others were examined for AQP4 and TRPM7 mRNA changes. RESULTS: Compared with the model group, the neurologic deficit scores and Na+ levels decreased in the lactuside B groups (p < 0.05 vs. p < 0.01). All lactuside B groups had significantly decreased AQP4 and TRPM7 mRNA expression compared with the model group (p < 0.05 vs. < 0.01). Dose dependence was observed between low and medium doses. CONCLUSIONS: Lactuside B protected against cerebral edema and nerve cell damage caused by cerebral ischemic injury by decreasing the expression of AQP4 and TRPM7 mRNAs in the cerebral cortex of rats.
  • |Animals[MESH]
  • |Aquaporin 4/*genetics[MESH]
  • |Brain Edema/genetics/metabolism/prevention & control[MESH]
  • |Cerebral Cortex/*drug effects/metabolism/pathology[MESH]
  • |Cytoprotection[MESH]
  • |Disease Models, Animal[MESH]
  • |Dose-Response Relationship, Drug[MESH]
  • |Down-Regulation[MESH]
  • |Drug Administration Schedule[MESH]
  • |Glucosides/administration & dosage/*pharmacology[MESH]
  • |Infarction, Middle Cerebral Artery/*drug therapy/genetics/metabolism/pathology[MESH]
  • |Injections, Intraperitoneal[MESH]
  • |Male[MESH]
  • |Neuroprotective Agents/administration & dosage/*pharmacology[MESH]
  • |RNA, Messenger/*metabolism[MESH]
  • |Rats[MESH]
  • |Rats, Sprague-Dawley[MESH]
  • |Sodium/metabolism[MESH]
  • |TRPM Cation Channels/*genetics[MESH]


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