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10.2215/CJN.08860813

http://scihub22266oqcxt.onion/10.2215/CJN.08860813
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24789550!4078957!24789550
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suck abstract from ncbi


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pmid24789550      Clin+J+Am+Soc+Nephrol 2014 ; 9 (7): 1272-81
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  • Homeostasis, the milieu interieur, and the wisdom of the nephron #MMPMID24789550
  • Hoenig MP; Zeidel ML
  • Clin J Am Soc Nephrol 2014[Jul]; 9 (7): 1272-81 PMID24789550show ga
  • The concept of homeostasis has been inextricably linked to the function of the kidneys for more than a century when it was recognized that the kidneys had the ability to maintain the "internal milieu" and allow organisms the "physiologic freedom" to move into varying environments and take in varying diets and fluids. Early ingenious, albeit rudimentary, experiments unlocked a wealth of secrets on the mechanisms involved in the formation of urine and renal handling of the gamut of electrolytes, as well as that of water, acid, and protein. Recent scientific advances have confirmed these prescient postulates such that the modern clinician is the beneficiary of a rich understanding of the nephron and the kidney's critical role in homeostasis down to the molecular level. This review summarizes those early achievements and provides a framework and introduction for the new CJASN series on renal physiology.
  • |*Glomerular Filtration Rate[MESH]
  • |*Renal Reabsorption[MESH]
  • |Acid-Base Equilibrium[MESH]
  • |Animals[MESH]
  • |Humans[MESH]
  • |Hydrogen-Ion Concentration[MESH]
  • |Nephrons/*physiology/ultrastructure[MESH]
  • |Phosphates/metabolism[MESH]
  • |Potassium/metabolism[MESH]
  • |Proteins/metabolism[MESH]
  • |Sodium/metabolism[MESH]
  • |Water-Electrolyte Balance[MESH]


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