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10.1111/cei.12359 http://scihub22266oqcxt.onion/10.1111/cei.12359 24758196!4260898!24758196     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24758196&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Clin+Exp+Immunol 2015 ; 179 (1): 68-74 Nephropedia Template TP {{tp|p=24758196|t=2015. Acetylated histones contribute to the immunostimulatory potential of neutrophil extracellular traps in systemic lupus erythematosus |pdf=|usr=}}{{24758196}} gab.com Text Acetylated histones contribute to the immunostimulatory potential of neutrophil extracellular traps in systemic lupus erythematosus JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24758196 #FOAvip In addition to disturbed apoptosis and insufficient clearance of apoptotic cells, there is recent evidence for a role of neutrophils in the aetiopathogenesis of systemic lupus erythematosus (SLE). In response to various stimuli, neutrophils can rapidly release DNA fibres decorated with citrullinated histones and anti-microbial peptides. These structures are referred to as neutrophil extracellular traps (NETs). In addition to apoptotic cell-derived microparticles, these NETs may comprise a further source of autoantigens, able to drive the autoimmune response in SLE. Our group recently identified specific histone modifications occurring during apoptosis that play an important role in the autoimmune response in SLE. In the current study, we evaluated the presence and immunostimulatory potential of these previously identified histone modifications in NETs. Compared to NETs from healthy donors, the histones present in NETs formed by SLE-derived neutrophils contain increased amounts of acetylated and methylated residues, which we previously observed to be associated with apoptosis and SLE. Treatment of neutrophils with histone deacetylase (HDAC) inhibitor Trichostatin A (TSA), prior to induction of NETosis, induced NETs containing hyperacetylated histones, endowed with an increased capacity to activate macrophages. This implies that specific histone modifications, in particular acetylation, might enhance the immunostimulatory potential of NETs in SLE. Twit Text FOAVip Acetylated histones contribute to the immunostimulatory potential of neutrophil extracellular traps in systemic lupus erythematosus ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24758196 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24758196 #FOAvip English Wikipedia <ref>{{Cite pmid|24758196}}</ref> Acetylated histones contribute to the immunostimulatory potential of neutrophil extracellular traps in systemic lupus erythematosus #MMPMID24758196 Pieterse E; Hofstra J; Berden J; Herrmann M; Dieker J; van der Vlag J Clin Exp Immunol 2015[Jan]; 179 (1): 68-74 PMID24758196show ga In addition to disturbed apoptosis and insufficient clearance of apoptotic cells, there is recent evidence for a role of neutrophils in the aetiopathogenesis of systemic lupus erythematosus (SLE). In response to various stimuli, neutrophils can rapidly release DNA fibres decorated with citrullinated histones and anti-microbial peptides. These structures are referred to as neutrophil extracellular traps (NETs). In addition to apoptotic cell-derived microparticles, these NETs may comprise a further source of autoantigens, able to drive the autoimmune response in SLE. Our group recently identified specific histone modifications occurring during apoptosis that play an important role in the autoimmune response in SLE. In the current study, we evaluated the presence and immunostimulatory potential of these previously identified histone modifications in NETs. Compared to NETs from healthy donors, the histones present in NETs formed by SLE-derived neutrophils contain increased amounts of acetylated and methylated residues, which we previously observed to be associated with apoptosis and SLE. Treatment of neutrophils with histone deacetylase (HDAC) inhibitor Trichostatin A (TSA), prior to induction of NETosis, induced NETs containing hyperacetylated histones, endowed with an increased capacity to activate macrophages. This implies that specific histone modifications, in particular acetylation, might enhance the immunostimulatory potential of NETs in SLE. |Acetylation[MESH] |Adult[MESH] |Aged[MESH] |Apoptosis/immunology[MESH] |Case-Control Studies[MESH] |Extracellular Traps/*immunology[MESH] |Female[MESH] |Histones/*metabolism[MESH] |Humans[MESH] |Lupus Erythematosus, Systemic/drug therapy/*immunology/*metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Neutrophils/*immunology/*metabolism[MESH]Acetylated histones contribute to the immunostimulatory potential of n(epmc).pdf DeepDyve Pubget Overpricing