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http://scihub22266oqcxt.onion/ 2473355!ä!2473355 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cardiovasc+Pharmacol 1989 ; 13 Suppl 6 (ä): S69-74 Nephropedia Template TP {{tp|p=2473355|t=1989. Atrial natriuretic factor administered to humans: 1984-1988 |pdf=|usr=}}{{2473355}} gab.com Text Atrial natriuretic factor administered to humans: 1984-1988 JO: J Cardiovasc Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=2473355 #FOAvip In initial studies of human atrial natriuretic factor (ANF) administered to man, 100 microns intravenous bolus doses infused in normal volunteers and patients with essential hypertension resulted in clear increases in urinary excretion of sodium (four- to sixfold), urine volume, calcium, magnesium, and phosphorous. In addition, in both groups an acute but short-lived fall in blood pressure and rise in heart rate was observed. In these studies and other high dose constant infusion experiments, the response of the renin-angiotension-aldosterone system and plasma catecholamines was varied, either remaining unchanged or showing stimulation when high doses of ANF caused acute and substantial falls in blood pressure. In contrast, constant low-dose infusions of ANF in both normal and hypertensive man (0.75-2 pmol/kg/min) have consistently shown clear suppression of plasma concentrations of renin, angiotensin II, and aldosterone by at least 50% of baseline values. Such "physiological" doses of ANF are not associated with sympathetic nervous system activation even though subtle but significant falls in blood pressure (particularly systolic) may occur. Twit Text FOAVip Atrial natriuretic factor administered to humans: 1984-1988 ????J Cardiovasc Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=2473355 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2473355 #FOAvip English Wikipedia <ref>{{Cite pmid|2473355}}</ref> Atrial natriuretic factor administered to humans: 1984-1988 #MMPMID2473355 Richards AM J Cardiovasc Pharmacol 1989[]; 13 Suppl 6 (ä): S69-74 PMID2473355show ga In initial studies of human atrial natriuretic factor (ANF) administered to man, 100 microns intravenous bolus doses infused in normal volunteers and patients with essential hypertension resulted in clear increases in urinary excretion of sodium (four- to sixfold), urine volume, calcium, magnesium, and phosphorous. In addition, in both groups an acute but short-lived fall in blood pressure and rise in heart rate was observed. In these studies and other high dose constant infusion experiments, the response of the renin-angiotension-aldosterone system and plasma catecholamines was varied, either remaining unchanged or showing stimulation when high doses of ANF caused acute and substantial falls in blood pressure. In contrast, constant low-dose infusions of ANF in both normal and hypertensive man (0.75-2 pmol/kg/min) have consistently shown clear suppression of plasma concentrations of renin, angiotensin II, and aldosterone by at least 50% of baseline values. Such "physiological" doses of ANF are not associated with sympathetic nervous system activation even though subtle but significant falls in blood pressure (particularly systolic) may occur. |Atrial Natriuretic Factor/*pharmacology/therapeutic use[MESH] |Heart Failure/drug therapy[MESH] |Humans[MESH]Atrial natriuretic factor administered to humans: 1984-1988 (epmc).pdf DeepDyve Pubget Overpricing