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10.1097/QAD.0000000000000291 http://scihub22266oqcxt.onion/10.1097/QAD.0000000000000291 24732776/?report=reader!4300098!24732776     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24732776&cmd=llinks): Failed to open stream: HTTP request failed! 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Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine |pdf=|usr=}}{{24732776}} gab.com Text Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine JO: AIDS http://www.kidney.de/pget.php?&tw=1&pmid=24732776 #FOAvip OBJECTIVE: We explored the antiviral therapeutic potential of ibudilast (AV411, MN-166) and its amino analog, AV1013. METHODS: We analyzed whether Ibudilast, a nonselective cyclic AMP phosphodiesterase inhibitor that has been used clinically in Asia for bronchial asthma, poststroke dizziness, and ocular allergies, and AV1013, attenuate HIV-1 replication and the synergistic interactions seen with opiate abuse-HIV-1 comorbidity in neuronal death and inflammation. RESULTS: AV411 and AV1013 inhibited replication by HIV-1 in microglia and significantly suppressed Tat +/- morphine-induced tumor necrosis factor-alpha and MIF production, the activation of the nuclear factor-kappa B subunit p65, and neuronal death. AV411 and AV1013 prevented HIV-1 replication, and attenuated tumor necrosis factor-alpha and MIF release at concentrations of 100 nmol/l and 1 mumol/l, which are likely achievable at clinical doses. More importantly, co-exposure with morphine did not negate the inhibitory actions of AV411. CONCLUSION: Collectively, our data suggest that AV411 and its amino analog, AV1013, may be useful neuroprotective agents counteracting neurotoxicity caused by infected and activated glia, and implicate them as potential therapies for the management of HIV-associated neurocognitive disorders in an opioid-abusing population. Twit Text FOAVip Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine ????AIDS http://www.kidney.de/pget.php?&tw=1&pmid=24732776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24732776 #FOAvip English Wikipedia <ref>{{Cite pmid|24732776}}</ref> Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine #MMPMID24732776 El-Hage N; Rodriguez M; Podhaizer EM; Zou S; Dever SM; Snider SE; Knapp PE; Beardsley PM; Hauser KF AIDS 2014[Jun]; 28 (10): 1409-19 PMID24732776show ga OBJECTIVE: We explored the antiviral therapeutic potential of ibudilast (AV411, MN-166) and its amino analog, AV1013. METHODS: We analyzed whether Ibudilast, a nonselective cyclic AMP phosphodiesterase inhibitor that has been used clinically in Asia for bronchial asthma, poststroke dizziness, and ocular allergies, and AV1013, attenuate HIV-1 replication and the synergistic interactions seen with opiate abuse-HIV-1 comorbidity in neuronal death and inflammation. RESULTS: AV411 and AV1013 inhibited replication by HIV-1 in microglia and significantly suppressed Tat +/- morphine-induced tumor necrosis factor-alpha and MIF production, the activation of the nuclear factor-kappa B subunit p65, and neuronal death. AV411 and AV1013 prevented HIV-1 replication, and attenuated tumor necrosis factor-alpha and MIF release at concentrations of 100 nmol/l and 1 mumol/l, which are likely achievable at clinical doses. More importantly, co-exposure with morphine did not negate the inhibitory actions of AV411. CONCLUSION: Collectively, our data suggest that AV411 and its amino analog, AV1013, may be useful neuroprotective agents counteracting neurotoxicity caused by infected and activated glia, and implicate them as potential therapies for the management of HIV-associated neurocognitive disorders in an opioid-abusing population. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Cell Survival/drug effects[MESH] |Cells, Cultured[MESH] |HIV-1/*physiology[MESH] |Mice[MESH] |Morphine/*toxicity[MESH] |Neurons/*drug effects/physiology[MESH] |Neuroprotective Agents/*pharmacology[MESH]Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and(epmc).pdf DeepDyve Pubget Overpricing