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http://scihub22266oqcxt.onion/ 2472760!ä!2472760 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Allergy 1989 ; 63 (1): 39-46 Nephropedia Template TP {{tp|p=2472760|t=1989. Pharmacologic modulation of spontaneous histamine release |pdf=|usr=}}{{2472760}} gab.com Text Pharmacologic modulation of spontaneous histamine release JO: Ann Allergy http://www.kidney.de/pget.php?&tw=1&pmid=2472760 #FOAvip In a previous study from our laboratory (Akagi and Townley) we reported that basophils from asthmatic patients off medication show spontaneous histamine release (SHR) significantly higher than asthmatic patients on chronic medication. Both groups of asthmatics showed significantly higher SHR than normal subjects. These findings led us to test the in vitro effect of various therapeutic agents on SHR. Theophylline exerted the most pronounced inhibitory effect on SHR (P less than .005). The effects of isoproterenol and PGE1 were significant (P less than .005) but less than theophylline. These in vitro findings led us to evaluate the effect of a single dose, orally administered bronchodilator on in vitro SHR from asthmatic subjects. The effect of theophylline 250 mg and metaproterenol 20 mg on pulmonary function and SHR was evaluated on separate study days. Four of the eight asthmatic subjects showed greater than 10% SHR. The baseline value of SHR in the same individuals on two different study days showed significant correlation (r = .82). A single dose of metaproterenol or theophylline increased the pulmonary function but failed to influence the SHR. Although SHR occurs in asthmatic subjects, it is not influenced by single dose bronchodilation. Twit Text FOAVip Pharmacologic modulation of spontaneous histamine release ????Ann Allergy http://www.kidney.de/pget.php?&tw=1&pmid=2472760 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2472760 #FOAvip English Wikipedia <ref>{{Cite pmid|2472760}}</ref> Pharmacologic modulation of spontaneous histamine release #MMPMID2472760 Akagi K; Kohi F; Trivedi R; Townley RG Ann Allergy 1989[Jul]; 63 (1): 39-46 PMID2472760show ga In a previous study from our laboratory (Akagi and Townley) we reported that basophils from asthmatic patients off medication show spontaneous histamine release (SHR) significantly higher than asthmatic patients on chronic medication. Both groups of asthmatics showed significantly higher SHR than normal subjects. These findings led us to test the in vitro effect of various therapeutic agents on SHR. Theophylline exerted the most pronounced inhibitory effect on SHR (P less than .005). The effects of isoproterenol and PGE1 were significant (P less than .005) but less than theophylline. These in vitro findings led us to evaluate the effect of a single dose, orally administered bronchodilator on in vitro SHR from asthmatic subjects. The effect of theophylline 250 mg and metaproterenol 20 mg on pulmonary function and SHR was evaluated on separate study days. Four of the eight asthmatic subjects showed greater than 10% SHR. The baseline value of SHR in the same individuals on two different study days showed significant correlation (r = .82). A single dose of metaproterenol or theophylline increased the pulmonary function but failed to influence the SHR. Although SHR occurs in asthmatic subjects, it is not influenced by single dose bronchodilation. |Adult[MESH] |Alprostadil/pharmacology[MESH] |Asthma/physiopathology[MESH] |Basophils/drug effects/*immunology[MESH] |Calcium[MESH] |Dimaprit[MESH] |Forced Expiratory Volume[MESH] |Histamine Release/*drug effects[MESH] |Humans[MESH] |Isoproterenol/pharmacology[MESH] |Magnesium[MESH] |Male[MESH] |Metaproterenol/pharmacology[MESH] |Temperature[MESH] |Theophylline/administration & dosage/pharmacology[MESH] |Thiourea/pharmacology[MESH]Pharmacologic modulation of spontaneous histamine release (epmc).pdf DeepDyve Pubget Overpricing