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10.1016/j.immuni.2014.02.013 http://scihub22266oqcxt.onion/10.1016/j.immuni.2014.02.013 24726877!ä!24726877 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2014 ; 40 (4): 554-68 Nephropedia Template TP {{tp|p=24726877|t=2014. Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages |pdf=|usr=}}{{24726877}} gab.com Text Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=24726877 #FOAvip Aspirin gained tremendous popularity during the 1918 Spanish Influenza virus pandemic, 50 years prior to the demonstration of their inhibitory action on prostaglandins. Here, we show that during influenza A virus (IAV) infection, prostaglandin E2 (PGE2) was upregulated, which led to the inhibition of type I interferon (IFN) production and apoptosis in macrophages, thereby causing an increase in virus replication. This inhibitory role of PGE2 was not limited to innate immunity, because both antigen presentation and T cell mediated immunity were also suppressed. Targeted PGE2 suppression via genetic ablation of microsomal prostaglandin E-synthase 1 (mPGES-1) or by the pharmacological inhibition of PGE2 receptors EP2 and EP4 substantially improved survival against lethal IAV infection whereas PGE2 administration reversed this phenotype. These data demonstrate that the mPGES-1-PGE2 pathway is targeted by IAV to evade host type I IFN-dependent antiviral immunity. We propose that specific inhibition of PGE2 signaling might serve as a treatment for IAV. Twit Text FOAVip Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=24726877 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24726877 #FOAvip English Wikipedia <ref>{{Cite pmid|24726877}}</ref> Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages #MMPMID24726877 Coulombe F; Jaworska J; Verway M; Tzelepis F; Massoud A; Gillard J; Wong G; Kobinger G; Xing Z; Couture C; Joubert P; Fritz JH; Powell WS; Divangahi M Immunity 2014[Apr]; 40 (4): 554-68 PMID24726877show ga Aspirin gained tremendous popularity during the 1918 Spanish Influenza virus pandemic, 50 years prior to the demonstration of their inhibitory action on prostaglandins. Here, we show that during influenza A virus (IAV) infection, prostaglandin E2 (PGE2) was upregulated, which led to the inhibition of type I interferon (IFN) production and apoptosis in macrophages, thereby causing an increase in virus replication. This inhibitory role of PGE2 was not limited to innate immunity, because both antigen presentation and T cell mediated immunity were also suppressed. Targeted PGE2 suppression via genetic ablation of microsomal prostaglandin E-synthase 1 (mPGES-1) or by the pharmacological inhibition of PGE2 receptors EP2 and EP4 substantially improved survival against lethal IAV infection whereas PGE2 administration reversed this phenotype. These data demonstrate that the mPGES-1-PGE2 pathway is targeted by IAV to evade host type I IFN-dependent antiviral immunity. We propose that specific inhibition of PGE2 signaling might serve as a treatment for IAV. |Animals[MESH] |Antigen Presentation/drug effects[MESH] |Apoptosis/drug effects[MESH] |Cells, Cultured[MESH] |Dinoprostone/immunology/*metabolism[MESH] |Gene Expression Regulation/drug effects[MESH] |Immunity/drug effects/genetics[MESH] |Influenza A virus/*physiology[MESH] |Interferon Type I/genetics/*metabolism[MESH] |Intramolecular Oxidoreductases/*antagonists & inhibitors/genetics[MESH] |Macrophages/*drug effects/immunology/virology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Molecular Targeted Therapy[MESH] |Orthomyxoviridae Infections/*drug therapy/immunology[MESH] |Prostaglandin-E Synthases[MESH] |Receptors, Prostaglandin E, EP2 Subtype/antagonists & inhibitors[MESH] |Receptors, Prostaglandin E, EP4 Subtype/antagonists & inhibitors[MESH] |T-Lymphocytes/immunology/virology[MESH]Targeted prostaglandin E2 inhibition enhances antiviral immunity throu(epmc).pdf DeepDyve Pubget Overpricing