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TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration #MMPMID24724725
Nielsen N; Lindemann O; Schwab A
Br J Pharmacol 2014[Dec]; 171 (24): 5524-40 PMID24724725show ga
Cancer cells are strongly influenced by host cells within the tumour stroma and vice versa. This leads to the development of a tumour microenvironment with distinct physical and chemical properties that are permissive for tumour progression. The ability to migrate plays a central role in this mutual interaction. Migration of cancer cells is considered as a prerequisite for tumour metastasis and the migration of host stromal cells is required for reaching the tumour site. Increasing evidence suggests that transient receptor potential (TRP) channels and STIM/ORAI proteins affect key calcium-dependent mechanisms implicated in both cancer and stroma cell migration. These include, among others, cytoskeletal remodelling, growth factor/cytokine signalling and production, and adaptation to tumour microenvironmental properties such as hypoxia and oxidative stress. In this review, we will summarize the current knowledge regarding TRP channels and STIM/ORAI proteins in cancer and stroma cell migration. We focus on how TRP channel or STIM/ORAI-mediated Ca(2+) signalling directly or indirectly influences cancer and stroma cell migration by affecting the above listed mechanisms. LINKED ARTICLES: This article is part of a themed section on Cytoskeleton, Extracellular Matrix, Cell Migration, Wound Healing and Related Topics. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-24.
|*Neoplasm Metastasis[MESH]
|Adaptation, Physiological[MESH]
|Calcium Channels/*metabolism[MESH]
|Calcium/*metabolism[MESH]
|Cell Movement/*physiology[MESH]
|Cytokines/metabolism[MESH]
|Cytoskeleton/metabolism[MESH]
|Humans[MESH]
|Intercellular Signaling Peptides and Proteins/metabolism[MESH]
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Br+J+Pharmacol 2014 ; 171 (24): 5524-40
