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10.1002/eji.201344359 http://scihub22266oqcxt.onion/10.1002/eji.201344359 24687623!ä!24687623 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2014 ; 44 (7): 2003-12 Nephropedia Template TP {{tp|p=24687623|t=2014. Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity |pdf=|usr=}}{{24687623}} gab.com Text Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24687623 #FOAvip Alveolar macrophages (AMs), localized at the pulmonary air-tissue interface, are one of the first lines of defense that interact with inhaled airborne pathogens such as influenza viruses. By using a new CD169-DTR transgenic mouse strain we demonstrate that specific and highly controlled in vivo ablation of this myeloid cell subset leads to severe impairment of the innate, but not adaptive, immune responses and critically affects the progression of the disease. In fact, AM-ablated mice, infected with a normally sublethal dose of PR8 influenza virus, showed dramatically increased virus load in the lungs, severe airway inflammation, pulmonary edema and vascular leakage, which caused the death of the infected animals. Our data highlight the possibilities for new therapeutic strategies focusing on modulation of AMs, which may efficiently boost innate responses to influenza infections. Twit Text FOAVip Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24687623 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24687623 #FOAvip English Wikipedia <ref>{{Cite pmid|24687623}}</ref> Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity #MMPMID24687623 Purnama C; Ng SL; Tetlak P; Setiagani YA; Kandasamy M; Baalasubramanian S; Karjalainen K; Ruedl C Eur J Immunol 2014[Jul]; 44 (7): 2003-12 PMID24687623show ga Alveolar macrophages (AMs), localized at the pulmonary air-tissue interface, are one of the first lines of defense that interact with inhaled airborne pathogens such as influenza viruses. By using a new CD169-DTR transgenic mouse strain we demonstrate that specific and highly controlled in vivo ablation of this myeloid cell subset leads to severe impairment of the innate, but not adaptive, immune responses and critically affects the progression of the disease. In fact, AM-ablated mice, infected with a normally sublethal dose of PR8 influenza virus, showed dramatically increased virus load in the lungs, severe airway inflammation, pulmonary edema and vascular leakage, which caused the death of the infected animals. Our data highlight the possibilities for new therapeutic strategies focusing on modulation of AMs, which may efficiently boost innate responses to influenza infections. |*Adaptive Immunity[MESH] |*Influenza A Virus, H1N1 Subtype[MESH] |Animals[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |Dendritic Cells/physiology[MESH] |Female[MESH] |Lung/virology[MESH] |Macrophages, Alveolar/*physiology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Orthomyxoviridae Infections/*immunology/pathology/virology[MESH] |Sialic Acid Binding Ig-like Lectin 1/physiology[MESH]Transient ablation of alveolar macrophages leads to massive pathology (epmc).pdf DeepDyve Pubget Overpricing