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10.4161/cam.28182 http://scihub22266oqcxt.onion/10.4161/cam.28182 24658050!4198351!24658050     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24658050&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cell+Adh+Migr 2014 ; 8 (3): 268-72 Nephropedia Template TP {{tp|p=24658050|t=2014. Spatiotemporal organization and mechanosensory function of podosomes |pdf=|usr=}}{{24658050}} gab.com Text Spatiotemporal organization and mechanosensory function of podosomes JO: Cell Adh Migr http://www.kidney.de/pget.php?&tw=1&pmid=24658050 #FOAvip Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are associated with an actin network and often organize into large clusters. Recent results from our laboratory and others have shed new light on podosome structure and dynamics, suggesting a revision of the classical "core-ring" model. Also, these studies demonstrate that the adhesive and protrusive module are functionally linked by the actin network likely facilitating mechanotransduction as well as providing feedback between these two modules. In this commentary, we briefly summarize these recent advances with respect to the knowledge on podosome structure and discuss force distribution mechanisms within podosomes and their emerging role in mechanotransduction. Twit Text FOAVip Spatiotemporal organization and mechanosensory function of podosomes ????Cell Adh Migr http://www.kidney.de/pget.php?&tw=1&pmid=24658050 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24658050 #FOAvip English Wikipedia <ref>{{Cite pmid|24658050}}</ref> Spatiotemporal organization and mechanosensory function of podosomes #MMPMID24658050 van den Dries K; Bolomini-Vittori M; Cambi A Cell Adh Migr 2014[]; 8 (3): 268-72 PMID24658050show ga Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are associated with an actin network and often organize into large clusters. Recent results from our laboratory and others have shed new light on podosome structure and dynamics, suggesting a revision of the classical "core-ring" model. Also, these studies demonstrate that the adhesive and protrusive module are functionally linked by the actin network likely facilitating mechanotransduction as well as providing feedback between these two modules. In this commentary, we briefly summarize these recent advances with respect to the knowledge on podosome structure and discuss force distribution mechanisms within podosomes and their emerging role in mechanotransduction. |Actins/metabolism[MESH] |Animals[MESH] |Cell Adhesion/*physiology[MESH] |Cell Movement/physiology[MESH] |Humans[MESH]Spatiotemporal organization and mechanosensory function of podosomes (epmc).pdf DeepDyve Pubget Overpricing