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10.1016/j.addbeh.2014.02.015 http://scihub22266oqcxt.onion/10.1016/j.addbeh.2014.02.015 24642345/?report=reader!4026273!24642345     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Addict+Behav 2014 ; 39 (6): 1057-61 Nephropedia Template TP {{tp|p=24642345|t=2014. Preliminary evidence for normalization of risk taking by modafinil in chronic cocaine users |pdf=|usr=}}{{24642345}} gab.com Text Preliminary evidence for normalization of risk taking by modafinil in chronic cocaine users JO: Addict Behav http://www.kidney.de/pget.php?&tw=1&pmid=24642345 #FOAvip Modafinil, a wake-promoting agent used to treat sleep disorders, is thought to enhance cognition. Although modafinil has shown promise as a pharmacotherapy for the treatment of cocaine dependence, it is unknown to what extent cognitive effects may play a role in such treatment. We examined the effect of modafinil on the Balloon Analogue Risk Task (BART), a behavioral measure in which higher scores are purported to reflect a greater propensity for risk-taking. Thirty cocaine dependent individuals, enrolled in a randomized clinical trial of modafinil 400mg (n=12) versus placebo (n=18), were administered the BART during the second week of inpatient treatment for cocaine dependence. A comparison cohort of healthy participants (n=19) performed the BART under similar conditions. Modafinil treatment was associated with significantly higher BART scores (p=0.01), which were comparable to scores in healthy persons. BART scores in placebo treated participants were much lower than previously reported in healthy participants, and lower than those observed in the comparison cohort. As propensity toward risk taking is typically associated with higher BART scores as well as increased risk for substance use, our findings may reflect a novel aspect of cognitive impairment related to chronic cocaine use. Notably, the low BART scores reflect highly suboptimal performance on the task, and the observed effect of modafinil may indicate a normalization of this impairment and have implications for treatment outcome. Twit Text FOAVip Preliminary evidence for normalization of risk taking by modafinil in chronic cocaine users ????Addict Behav http://www.kidney.de/pget.php?&tw=1&pmid=24642345 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24642345 #FOAvip English Wikipedia <ref>{{Cite pmid|24642345}}</ref> Preliminary evidence for normalization of risk taking by modafinil in chronic cocaine users #MMPMID24642345 Canavan SV; Forselius EL; Bessette AJ; Morgan PT Addict Behav 2014[Jun]; 39 (6): 1057-61 PMID24642345show ga Modafinil, a wake-promoting agent used to treat sleep disorders, is thought to enhance cognition. Although modafinil has shown promise as a pharmacotherapy for the treatment of cocaine dependence, it is unknown to what extent cognitive effects may play a role in such treatment. We examined the effect of modafinil on the Balloon Analogue Risk Task (BART), a behavioral measure in which higher scores are purported to reflect a greater propensity for risk-taking. Thirty cocaine dependent individuals, enrolled in a randomized clinical trial of modafinil 400mg (n=12) versus placebo (n=18), were administered the BART during the second week of inpatient treatment for cocaine dependence. A comparison cohort of healthy participants (n=19) performed the BART under similar conditions. Modafinil treatment was associated with significantly higher BART scores (p=0.01), which were comparable to scores in healthy persons. BART scores in placebo treated participants were much lower than previously reported in healthy participants, and lower than those observed in the comparison cohort. As propensity toward risk taking is typically associated with higher BART scores as well as increased risk for substance use, our findings may reflect a novel aspect of cognitive impairment related to chronic cocaine use. Notably, the low BART scores reflect highly suboptimal performance on the task, and the observed effect of modafinil may indicate a normalization of this impairment and have implications for treatment outcome. |*Risk-Taking[MESH] |Adult[MESH] |Benzhydryl Compounds/*therapeutic use[MESH] |Chronic Disease[MESH] |Cocaine-Related Disorders/*drug therapy/*psychology[MESH] |Cognition/drug effects[MESH] |Cohort Studies[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Modafinil[MESH] |Task Performance and Analysis[MESH]Preliminary evidence for normalization of risk taking by modafinil in (epmc).pdf DeepDyve Pubget Overpricing