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10.1002/pmic.201300404

http://scihub22266oqcxt.onion/10.1002/pmic.201300404
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24610701!7167649!24610701
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suck abstract from ncbi


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pmid24610701      Proteomics 2014 ; 14 (11): 1403-23
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  • Comparative proteome analysis of tracheal tissues in response to infectious bronchitis coronavirus, Newcastle disease virus, and avian influenza virus H9 subtype virus infection #MMPMID24610701
  • Sun J; Han Z; Shao Y; Cao Z; Kong X; Liu S
  • Proteomics 2014[Jun]; 14 (11): 1403-23 PMID24610701show ga
  • Infectious bronchitis coronavirus (IBV), Newcastle disease virus (NDV), and avian influenza virus (AIV) H9 subtype are major pathogens of chickens causing serious respiratory tract disease and heavy economic losses. To better understand the replication features of these viruses in their target organs and molecular pathogenesis of these different viruses, comparative proteomic analysis was performed to investigate the proteome changes of primary target organ during IBV, NDV, and AIV H9 infections, using 2D-DIGE followed MALDI-TOF/TOF-MS. In total, 44, 39, 41, 48, and 38 proteins were identified in the tracheal tissues of the chickens inoculated with IBV (ck/CH/LDL/97I, H120), NDV (La Sota), and AIV H9, and between ck/CH/LDL/97I and H120, respectively. Bioinformatics analysis showed that IBV, NDV, and AIV H9 induced similar core host responses involved in biosynthetic, catabolic, metabolic, signal transduction, transport, cytoskeleton organization, macromolecular complex assembly, cell death, response to stress, and immune system process. Comparative analysis of host response induced by different viruses indicated differences in protein expression changes induced by IBV, NDV, and AIV H9 may be responsible for the specific pathogenesis of these different viruses. Our result reveals specific host response to IBV, NDV, and AIVH9 infections and provides insights into the distinct pathogenic mechanisms of these avian respiratory viruses.
  • |*Host-Pathogen Interactions[MESH]
  • |Animals[MESH]
  • |Bronchitis/genetics/metabolism/veterinary/virology[MESH]
  • |Chickens[MESH]
  • |Gene Expression Regulation[MESH]
  • |Influenza A virus/*physiology[MESH]
  • |Influenza in Birds/genetics/*metabolism[MESH]
  • |Newcastle Disease/genetics/*metabolism[MESH]
  • |Newcastle disease virus/*physiology[MESH]
  • |Proteome/analysis/genetics/*metabolism[MESH]


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