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beta-Lapachone ameliorates murine cisplatin nephrotoxicity: NAD(+), NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation #MMPMID24583980
Lu CY
Kidney Int 2014[Mar]; 85 (3): 496-8 PMID24583980show ga
The clinical utility of cisplatin is limited by nephrotoxicity. Oh et al. report that beta-lapachone prevents this nephrotoxicity but not cisplatin's cytotoxicity for cancers. In addition to its potential clinical importance, the beneficial effect of beta-lapachone on cisplatin acute kidney injury may illustrate fundamental processes that ordinarily link alterations in nutrient availability and intracellular reactive oxygen species on the one hand, with inflammation and cell death on the other hand.