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10.2340/00015555-1794 http://scihub22266oqcxt.onion/10.2340/00015555-1794 24577497!ä!24577497 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24577497&cmd=llinks): Failed to open stream: HTTP request failed! 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Clonality and anatomic distribution on the skin of antibiotic resistant and sensitive Propionibacterium acnes |pdf=|usr=}}{{24577497}} gab.com Text Clonality and anatomic distribution on the skin of antibiotic resistant and sensitive Propionibacterium acnes JO: Acta Derm Venereol http://www.kidney.de/pget.php?&tw=1&pmid=24577497 #FOAvip Increasing antibiotic resistance in the population of Propionibacterium acnes is a major concern. Our aims were to examine the clonal relationships and anatomical distribution of resistant and sensitive P. acnes. A collection of 350 P. acnes isolates was therefore used to determine the minimum inhibitory concentration of tetracycline, erythro-mycin and clindamycin, multilocus sequence type, and the identity of genetic resistance markers. Two hitherto unknown resistance mutations were detected. Resistant P. acnes mainly belonged to clonal clusters in division I-1a frequently isolated from skin and associated with moderate to severe acne. All high-level tetracycline resistant strains were members of a single clone. Multiple isolates from distinct anatomic areas of surface skin and follicles of 2 acne patients revealed substantial clonal diversity between areas and co-existence of resistant and sensitive clones. Fifty-two percent of Danish acne patients and 43% of controls carried at least one resistant P. acnes strain, resistance to clindamycin being most frequent followed by tetracycline and erythromycin. Resistance to tetracycline was detected exclusively among isolates from acne patients. In conclusion, antibiotic resistance is associated with particular evolutionary clades of P. acnes and a substantial part is due to a single geographically widespread clone (ST3). Individuals carry a strikingly complex population of P. acnes with distinct virulence potential and antibiotic resistance. Twit Text FOAVip Clonality and anatomic distribution on the skin of antibiotic resistant and sensitive Propionibacterium acnes ????Acta Derm Venereol http://www.kidney.de/pget.php?&tw=1&pmid=24577497 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24577497 #FOAvip English Wikipedia <ref>{{Cite pmid|24577497}}</ref> Clonality and anatomic distribution on the skin of antibiotic resistant and sensitive Propionibacterium acnes #MMPMID24577497 Lomholt HB; Kilian M Acta Derm Venereol 2014[Sep]; 94 (5): 534-8 PMID24577497show ga Increasing antibiotic resistance in the population of Propionibacterium acnes is a major concern. Our aims were to examine the clonal relationships and anatomical distribution of resistant and sensitive P. acnes. A collection of 350 P. acnes isolates was therefore used to determine the minimum inhibitory concentration of tetracycline, erythro-mycin and clindamycin, multilocus sequence type, and the identity of genetic resistance markers. Two hitherto unknown resistance mutations were detected. Resistant P. acnes mainly belonged to clonal clusters in division I-1a frequently isolated from skin and associated with moderate to severe acne. All high-level tetracycline resistant strains were members of a single clone. Multiple isolates from distinct anatomic areas of surface skin and follicles of 2 acne patients revealed substantial clonal diversity between areas and co-existence of resistant and sensitive clones. Fifty-two percent of Danish acne patients and 43% of controls carried at least one resistant P. acnes strain, resistance to clindamycin being most frequent followed by tetracycline and erythromycin. Resistance to tetracycline was detected exclusively among isolates from acne patients. In conclusion, antibiotic resistance is associated with particular evolutionary clades of P. acnes and a substantial part is due to a single geographically widespread clone (ST3). Individuals carry a strikingly complex population of P. acnes with distinct virulence potential and antibiotic resistance. |*Drug Resistance, Multiple, Bacterial[MESH] |Acne Vulgaris/*drug therapy/microbiology[MESH] |Anti-Bacterial Agents/*therapeutic use[MESH] |Case-Control Studies[MESH] |Denmark[MESH] |Gram-Positive Bacterial Infections/*drug therapy/genetics[MESH] |Humans[MESH]Clonality and anatomic distribution on the skin of antibiotic resistan(epmc).pdf DeepDyve Pubget Overpricing