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10.1002/cmdc.201300505 http://scihub22266oqcxt.onion/10.1002/cmdc.201300505 24574246!7162318!24574246     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ChemMedChem 2014 ; 9 (7): 1522-33 Nephropedia Template TP {{tp|p=24574246|t=2014. Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives |pdf=|usr=}}{{24574246}} gab.com Text Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives JO: ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=24574246 #FOAvip Dengue is a systemic viral infection that is transmitted to humans by Aedes mosquitoes. No vaccines or specific therapeutics are currently available for dengue. Lycorine, which is a natural plant alkaloid, has been shown to possess antiviral activities against flaviviruses. In this study, a series of novel lycorine derivatives were synthesized and assayed for their inhibition of dengue virus (DENV) in cell cultures. Among the lycorine analogues, 1-acetyllycorine exhibited the most potent anti-DENV activity (EC50 =0.4 muM) with a reduced cytotoxicity (CC50 >300 muM), which resulted in a selectivity index (CC50 /EC50 ) of more than 750. The ketones 1-acetyl-2-oxolycorine (EC50 =1.8 muM) and 2-oxolycorine (EC50 =0.5 muM) also exhibited excellent antiviral activities with low cytotoxicity. Structure-activity relationships for the lycorine derivatives against DENV are discussed. A three-dimensional quantitative structure-activity relationship model was established by using a comparative molecular-field analysis protocol in order to rationalize the experimental results. Further modifications of the hydroxy group at the C1 position with retention of a ketone at the C2 position could potentially lead to inhibitors with improved overall properties. Twit Text FOAVip Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives ????ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=24574246 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24574246 #FOAvip English Wikipedia <ref>{{Cite pmid|24574246}}</ref> Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives #MMPMID24574246 Wang P; Li LF; Wang QY; Shang LQ; Shi PY; Yin Z ChemMedChem 2014[Jul]; 9 (7): 1522-33 PMID24574246show ga Dengue is a systemic viral infection that is transmitted to humans by Aedes mosquitoes. No vaccines or specific therapeutics are currently available for dengue. Lycorine, which is a natural plant alkaloid, has been shown to possess antiviral activities against flaviviruses. In this study, a series of novel lycorine derivatives were synthesized and assayed for their inhibition of dengue virus (DENV) in cell cultures. Among the lycorine analogues, 1-acetyllycorine exhibited the most potent anti-DENV activity (EC50 =0.4 muM) with a reduced cytotoxicity (CC50 >300 muM), which resulted in a selectivity index (CC50 /EC50 ) of more than 750. The ketones 1-acetyl-2-oxolycorine (EC50 =1.8 muM) and 2-oxolycorine (EC50 =0.5 muM) also exhibited excellent antiviral activities with low cytotoxicity. Structure-activity relationships for the lycorine derivatives against DENV are discussed. A three-dimensional quantitative structure-activity relationship model was established by using a comparative molecular-field analysis protocol in order to rationalize the experimental results. Further modifications of the hydroxy group at the C1 position with retention of a ketone at the C2 position could potentially lead to inhibitors with improved overall properties. |Amaryllidaceae Alkaloids/chemical synthesis/*chemistry/pharmacology[MESH] |Antiviral Agents/chemical synthesis/*chemistry/pharmacology[MESH] |Dengue Virus/drug effects[MESH] |Molecular Conformation[MESH] |Phenanthridines/chemical synthesis/*chemistry/pharmacology[MESH]Anti-dengue-virus activity and structure-activity relationship studies(epmc).pdf DeepDyve Pubget Overpricing