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10.1093/aje/kwt433

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suck abstract from ncbi


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pmid24561991      Am+J+Epidemiol 2014 ; 179 (7): 834-42
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  • Neonatal genome-wide methylation patterns in relation to birth weight in the Norwegian Mother and Child Cohort #MMPMID24561991
  • Engel SM; Joubert BR; Wu MC; Olshan AF; Haberg SE; Ueland PM; Nystad W; Nilsen RM; Vollset SE; Peddada SD; London SJ
  • Am J Epidemiol 2014[Apr]; 179 (7): 834-42 PMID24561991show ga
  • Although epigenetic regulation plays a critical role in embryonic development, few studies have examined the relationship of epigenome-wide methylation with fetal growth. Using the Infinium HumanMethylation450 BeadChip (Illumina, Inc., San Diego, California) in a substudy of 1,046 infants from the Norwegian Mother and Child Cohort Study (MoBa) enrolled between 1999 and 2008, we examined epigenome-wide cord blood DNA methylation in relation to birth weight. In multivariable-adjusted robust linear regression models, we identified differential methylation at 19 cytosine-guanine dinucleotides (CpGs) associated with either decreased (AT-rich interactive domain 5B (MRF1-like) (ARID5B), 2 CpGs) or increased (x-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3), 4 CpGs) birth weight. ARID5B knockout mice have less adipose tissue and significantly lower weight in the postnatal period. XRCC3 plays a key role in the maintenance of chromosome stability and the repair of DNA damage. Although there are fewer data on the other implicated genes, many of these genes have been shown to have roles in developmental processes. This constitutes the largest and most robust study of birth weight using an epigenome-wide methylation platform and offers potential insights into epigenetic mechanisms of fetal growth.
  • |*Epigenesis, Genetic[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Base Composition/genetics[MESH]
  • |Birth Weight/*genetics[MESH]
  • |Cohort Studies[MESH]
  • |DNA Methylation/*genetics[MESH]
  • |DNA-Binding Proteins/*genetics[MESH]
  • |Female[MESH]
  • |Fetal Blood/*chemistry[MESH]
  • |Genome, Human[MESH]
  • |Genome-Wide Association Study[MESH]
  • |Humans[MESH]
  • |Infant, Newborn[MESH]
  • |Linear Models[MESH]
  • |Male[MESH]
  • |Norway[MESH]
  • |Pregnancy[MESH]
  • |Transcription Factors/*genetics[MESH]


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