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10.1016/s0006-291x(88)80421-2 http://scihub22266oqcxt.onion/10.1016/s0006-291x(88)80421-2 2454102!ä!2454102 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 1988 ; 152 (3): 1263-8 Nephropedia Template TP {{tp|p=2454102|t=1988. Amiloride increases the sensitivity of particulate guanylate cyclase to atrial natriuretic factor |pdf=|usr=}}{{2454102}} gab.com Text Amiloride increases the sensitivity of particulate guanylate cyclase to atrial natriuretic factor JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=2454102 #FOAvip The natriuretic agent amiloride induces a shift of the dose-response curve of particulate guanylate cyclase to atrial natriuretic factor (ANF) to the left. The ANF concentration for half-maximal activation of guanylate cyclase is shifted from 20 to 3 nM in the presence of 100 microM amiloride. This effect is observed with GTP*Mn2+, but not with GTP*Mg2+ as substrate. Amiloride derivatives, which inhibit a specific Na+-channel, also shift the dose-response curve to the left. These data suggest that some of the effects of amiloride may be mediated by an increased sensitivity of particulate guanylate cyclase to ANF. Twit Text FOAVip Amiloride increases the sensitivity of particulate guanylate cyclase to atrial natriuretic factor ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=2454102 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2454102 #FOAvip English Wikipedia <ref>{{Cite pmid|2454102}}</ref> Amiloride increases the sensitivity of particulate guanylate cyclase to atrial natriuretic factor #MMPMID2454102 Heim JM; Ivanova K; Gerzer R Biochem Biophys Res Commun 1988[May]; 152 (3): 1263-8 PMID2454102show ga The natriuretic agent amiloride induces a shift of the dose-response curve of particulate guanylate cyclase to atrial natriuretic factor (ANF) to the left. The ANF concentration for half-maximal activation of guanylate cyclase is shifted from 20 to 3 nM in the presence of 100 microM amiloride. This effect is observed with GTP*Mn2+, but not with GTP*Mg2+ as substrate. Amiloride derivatives, which inhibit a specific Na+-channel, also shift the dose-response curve to the left. These data suggest that some of the effects of amiloride may be mediated by an increased sensitivity of particulate guanylate cyclase to ANF. |Amiloride/analogs & derivatives/*pharmacology[MESH] |Animals[MESH] |Atrial Natriuretic Factor/*pharmacology[MESH] |Cattle[MESH] |Cyclic GMP/biosynthesis[MESH] |Dose-Response Relationship, Drug[MESH] |Guanosine Triphosphate/metabolism[MESH] |Guanylate Cyclase/*metabolism[MESH] |Ion Channels/drug effects[MESH] |Kinetics[MESH]Amiloride increases the sensitivity of particulate guanylate cyclase t(epmc).pdf DeepDyve Pubget Overpricing