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10.1089/ars.2014.5862 http://scihub22266oqcxt.onion/10.1089/ars.2014.5862 24512192!4545678!24512192     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24512192&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Antioxid+Redox+Signal 2015 ; 23 (5): 375-405 Nephropedia Template TP {{tp|p=24512192|t=2015. NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress |pdf=|usr=}}{{24512192}} gab.com Text NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress JO: Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=24512192 #FOAvip SIGNIFICANCE: NOX2 is important for host defense, and yet is implicated in a large number of diseases in which inflammation plays a role in pathogenesis. These include acute and chronic lung inflammatory diseases, stroke, traumatic brain injury, and neurodegenerative diseases, including Alzheimer's and Parkinson's Diseases. RECENT ADVANCES: Recent drug development programs have targeted several NOX isoforms that are implicated in a variety of diseases. The focus has been primarily on NOX4 and NOX1 rather than on NOX2, due, in part, to concerns about possible immunosuppressive side effects. Nevertheless, NOX2 clearly contributes to the pathogenesis of many inflammatory diseases, and its inhibition is predicted to provide a novel therapeutic approach. CRITICAL ISSUES: Possible side effects that might arise from targeting NOX2 are discussed, including the possibility that such inhibition will contribute to increased infections and/or autoimmune disorders. The state of the field with regard to existing NOX2 inhibitors and targeted development of novel inhibitors is also summarized. FUTURE DIRECTIONS: NOX2 inhibitors show particular promise for the treatment of inflammatory diseases, both acute and chronic. Theoretical side effects include pro-inflammatory and autoimmune complications and should be considered in any therapeutic program, but in our opinion, available data do not indicate that they are sufficiently likely to eliminate NOX2 as a drug target, particularly when weighed against the seriousness of many NOX2-related indications. Model studies demonstrating efficacy with minimal side effects are needed to encourage future development of NOX2 inhibitors as therapeutic agents. Twit Text FOAVip NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress ????Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=24512192 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24512192 #FOAvip English Wikipedia <ref>{{Cite pmid|24512192}}</ref> NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress #MMPMID24512192 Diebold BA; Smith SM; Li Y; Lambeth JD Antioxid Redox Signal 2015[Aug]; 23 (5): 375-405 PMID24512192show ga SIGNIFICANCE: NOX2 is important for host defense, and yet is implicated in a large number of diseases in which inflammation plays a role in pathogenesis. These include acute and chronic lung inflammatory diseases, stroke, traumatic brain injury, and neurodegenerative diseases, including Alzheimer's and Parkinson's Diseases. RECENT ADVANCES: Recent drug development programs have targeted several NOX isoforms that are implicated in a variety of diseases. The focus has been primarily on NOX4 and NOX1 rather than on NOX2, due, in part, to concerns about possible immunosuppressive side effects. Nevertheless, NOX2 clearly contributes to the pathogenesis of many inflammatory diseases, and its inhibition is predicted to provide a novel therapeutic approach. CRITICAL ISSUES: Possible side effects that might arise from targeting NOX2 are discussed, including the possibility that such inhibition will contribute to increased infections and/or autoimmune disorders. The state of the field with regard to existing NOX2 inhibitors and targeted development of novel inhibitors is also summarized. FUTURE DIRECTIONS: NOX2 inhibitors show particular promise for the treatment of inflammatory diseases, both acute and chronic. Theoretical side effects include pro-inflammatory and autoimmune complications and should be considered in any therapeutic program, but in our opinion, available data do not indicate that they are sufficiently likely to eliminate NOX2 as a drug target, particularly when weighed against the seriousness of many NOX2-related indications. Model studies demonstrating efficacy with minimal side effects are needed to encourage future development of NOX2 inhibitors as therapeutic agents. |*Drug Discovery[MESH] |Animals[MESH] |Enzyme Inhibitors/chemistry/metabolism/*therapeutic use[MESH] |Humans[MESH] |Inflammation/*drug therapy[MESH] |Membrane Glycoproteins/antagonists & inhibitors/*metabolism[MESH] |NADPH Oxidase 2[MESH]NOX2 As a Target for Drug Development: Indications, Possible Complicat(epmc).pdf DeepDyve Pubget Overpricing