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10.1111/jpi.12124 http://scihub22266oqcxt.onion/10.1111/jpi.12124 24499270!7166588!24499270     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24499270&cmd=llinks): Failed to open stream: HTTP request failed! 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Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus |pdf=|usr=}}{{24499270}} gab.com Text Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus JO: J Pineal Res http://www.kidney.de/pget.php?&tw=1&pmid=24499270 #FOAvip Autophagy is an important survival pathway and participates in the host response to infection. Beneficial effects of melatonin have been previously reported in an animal model of acute liver failure (ALF) induced by the rabbit hemorrhagic disease virus (RHDV). This study was aimed to investigate whether melatonin protection against liver injury induced by the RHDV associates to modulation of autophagy. Rabbits were infected with 2 x 10(4) hemagglutination units of a RHDV isolate and received 20 mg/kg melatonin at 0, 12, and 24 hr postinfection. RHDV induced autophagy, with increased expression of beclin-1, ubiquitin-like autophagy-related (Atg)5, Atg12, Atg16L1 and sequestrosome 1 (p62/SQSTM1), protein 1 light chain 3 (LC3) staining, and conversion of LC3-I to autophagosome-associated LC3-II. These effects reached a maximum at 24 hr postinfection, in parallel to extensive colocalization of LC3 and lysosome-associated membrane protein (LAMP)-1. The autophagic response induced by RHDV infection was significantly inhibited by melatonin administration. Melatonin treatment also resulted in decreased immunoreactivity for RHDV viral VP60 antigen and a significantly reduction in RHDV VP60 mRNA levels, oxidized to reduced glutathione ratio (GSSG/GSH), caspase-3 activity, and immunoglobulin-heavy-chain-binding protein (BiP) and CCAAT/enhancer-binding protein homologous protein (CHOP) expression. Results indicate that, in addition to its antioxidant and antiapoptotic effects, and the suppression of ER stress, melatonin induces a decrease in autophagy associated with RHDV infection and inhibits RHDV RNA replication. Results obtained reveal novel molecular pathways accounting for the protective effect of melatonin in this animal model of ALF. Twit Text FOAVip Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus ????J Pineal Res http://www.kidney.de/pget.php?&tw=1&pmid=24499270 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24499270 #FOAvip English Wikipedia <ref>{{Cite pmid|24499270}}</ref> Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus #MMPMID24499270 San-Miguel B; Crespo I; Vallejo D; Alvarez M; Prieto J; Gonzalez-Gallego J; Tunon MJ J Pineal Res 2014[Apr]; 56 (3): 313-21 PMID24499270show ga Autophagy is an important survival pathway and participates in the host response to infection. Beneficial effects of melatonin have been previously reported in an animal model of acute liver failure (ALF) induced by the rabbit hemorrhagic disease virus (RHDV). This study was aimed to investigate whether melatonin protection against liver injury induced by the RHDV associates to modulation of autophagy. Rabbits were infected with 2 x 10(4) hemagglutination units of a RHDV isolate and received 20 mg/kg melatonin at 0, 12, and 24 hr postinfection. RHDV induced autophagy, with increased expression of beclin-1, ubiquitin-like autophagy-related (Atg)5, Atg12, Atg16L1 and sequestrosome 1 (p62/SQSTM1), protein 1 light chain 3 (LC3) staining, and conversion of LC3-I to autophagosome-associated LC3-II. These effects reached a maximum at 24 hr postinfection, in parallel to extensive colocalization of LC3 and lysosome-associated membrane protein (LAMP)-1. The autophagic response induced by RHDV infection was significantly inhibited by melatonin administration. Melatonin treatment also resulted in decreased immunoreactivity for RHDV viral VP60 antigen and a significantly reduction in RHDV VP60 mRNA levels, oxidized to reduced glutathione ratio (GSSG/GSH), caspase-3 activity, and immunoglobulin-heavy-chain-binding protein (BiP) and CCAAT/enhancer-binding protein homologous protein (CHOP) expression. Results indicate that, in addition to its antioxidant and antiapoptotic effects, and the suppression of ER stress, melatonin induces a decrease in autophagy associated with RHDV infection and inhibits RHDV RNA replication. Results obtained reveal novel molecular pathways accounting for the protective effect of melatonin in this animal model of ALF. |Animals[MESH] |Autophagy/*drug effects[MESH] |Caliciviridae Infections/physiopathology/*prevention & control[MESH] |Disease Models, Animal[MESH] |Hemorrhagic Disease Virus, Rabbit/metabolism/*pathogenicity[MESH] |Liver Failure, Acute/*physiopathology[MESH] |Male[MESH] |Melatonin/*therapeutic use[MESH] |Rabbits[MESH]Melatonin modulates the autophagic response in acute liver failure ind(epmc).pdf DeepDyve Pubget Overpricing