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10.1155/2013/396839 http://scihub22266oqcxt.onion/10.1155/2013/396839 24490159/?report=reader!3893802!24490159     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2013 ; 2013 (ä): 396839 Nephropedia Template TP {{tp|p=24490159|t=2013. Novel strategies for the treatment of chondrosarcomas: targeting integrins |pdf=|usr=}}{{24490159}} gab.com Text Novel strategies for the treatment of chondrosarcomas: targeting integrins JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=24490159 #FOAvip Chondrosarcomas are a heterogeneous group of malignant bone tumors that are characterized by the production of cartilaginous extracellular matrix. They are the second most frequently occurring type of bone malignancy. Surgical resection remains the primary mode of treatment for chondrosarcomas, since conventional chemotherapy and radiotherapy are largely ineffective. Treatment of patients with high-grade chondrosarcomas is particularly challenging, owing to the lack of effective adjuvant therapies. Integrins are cell surface adhesion molecules that regulate a variety of cellular functions. They have been implicated in the initiation, progression, and metastasis of solid tumors. Deregulation of integrin expression and/or signaling has been identified in many chondrosarcomas. Therefore, the development of new drugs that can selectively target regulators of integrin gene expression and ligand-integrin signaling might hold great promise for the treatment of these cancers. In this review, we provide an overview of the current understanding of how growth factors, chemokines/cytokines, and other inflammation-related molecules can control the expression of specific integrins to promote cell migration. We also review the roles of specific subtypes of integrins and their signaling mechanisms, and discuss how these might be involved in tumor growth and metastasis. Finally, novel therapeutic strategies for targeting these molecules will be discussed. Twit Text FOAVip Novel strategies for the treatment of chondrosarcomas: targeting integrins ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=24490159 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24490159 #FOAvip English Wikipedia <ref>{{Cite pmid|24490159}}</ref> Novel strategies for the treatment of chondrosarcomas: targeting integrins #MMPMID24490159 Chen JC; Fong YC; Tang CH Biomed Res Int 2013[]; 2013 (ä): 396839 PMID24490159show ga Chondrosarcomas are a heterogeneous group of malignant bone tumors that are characterized by the production of cartilaginous extracellular matrix. They are the second most frequently occurring type of bone malignancy. Surgical resection remains the primary mode of treatment for chondrosarcomas, since conventional chemotherapy and radiotherapy are largely ineffective. Treatment of patients with high-grade chondrosarcomas is particularly challenging, owing to the lack of effective adjuvant therapies. Integrins are cell surface adhesion molecules that regulate a variety of cellular functions. They have been implicated in the initiation, progression, and metastasis of solid tumors. Deregulation of integrin expression and/or signaling has been identified in many chondrosarcomas. Therefore, the development of new drugs that can selectively target regulators of integrin gene expression and ligand-integrin signaling might hold great promise for the treatment of these cancers. In this review, we provide an overview of the current understanding of how growth factors, chemokines/cytokines, and other inflammation-related molecules can control the expression of specific integrins to promote cell migration. We also review the roles of specific subtypes of integrins and their signaling mechanisms, and discuss how these might be involved in tumor growth and metastasis. Finally, novel therapeutic strategies for targeting these molecules will be discussed. |*Molecular Targeted Therapy[MESH] |Bone Neoplasms/*drug therapy/genetics/pathology[MESH] |Cell Adhesion/genetics[MESH] |Chondrosarcoma/*drug therapy/genetics/pathology[MESH] |Extracellular Matrix/metabolism[MESH] |Gene Expression Regulation, Neoplastic[MESH] |Humans[MESH] |Integrins/*genetics/therapeutic use[MESH]Novel strategies for the treatment of chondrosarcomas: targeting integ(epmc).pdf DeepDyve Pubget Overpricing