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10.1038/nrm3737

http://scihub22266oqcxt.onion/10.1038/nrm3737
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24452471!ä!24452471

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suck abstract from ncbi


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pmid24452471      Nat+Rev+Mol+Cell+Biol 2014 ; 15 (2): 135-47
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  • Regulated necrosis: the expanding network of non-apoptotic cell death pathways #MMPMID24452471
  • Vanden Berghe T; Linkermann A; Jouan-Lanhouet S; Walczak H; Vandenabeele P
  • Nat Rev Mol Cell Biol 2014[Feb]; 15 (2): 135-47 PMID24452471show ga
  • Cell death research was revitalized by the understanding that necrosis can occur in a highly regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein kinase 1)- and RIPK3-MLKL (mixed lineage kinase domain-like)-mediated necroptosis is the most understood form of regulated necrosis, other examples of this process are emerging, including cell death mechanisms known as parthanatos, oxytosis, ferroptosis, NETosis, pyronecrosis and pyroptosis. Elucidating how these pathways of regulated necrosis are interconnected at the molecular level should enable this process to be therapeutically targeted.
  • |*Molecular Targeted Therapy[MESH]
  • |*Signal Transduction[MESH]
  • |Apoptosis/*genetics[MESH]
  • |Cell Death/genetics[MESH]
  • |Humans[MESH]
  • |Necrosis/*genetics/metabolism[MESH]
  • |Protein Kinases/genetics/metabolism[MESH]


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