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10.1002/embj.201284188 http://scihub22266oqcxt.onion/10.1002/embj.201284188 24434184!3983685!24434184     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2014 ; 33 (3): 229-46 Nephropedia Template TP {{tp|p=24434184|t=2014. FGF23 promotes renal calcium reabsorption through the TRPV5 channel |pdf=|usr=}}{{24434184}} gab.com Text FGF23 promotes renal calcium reabsorption through the TRPV5 channel JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=24434184 #FOAvip alphaKlotho is thought to activate the epithelial calcium channel Transient Receptor Potential Vanilloid-5 (TRPV5) in distal renal tubules through its putative glucuronidase/sialidase activity, thereby preventing renal calcium loss. However, alphaKlotho also functions as the obligatory co-receptor for fibroblast growth factor-23 (FGF23), a bone-derived phosphaturic hormone. Here, we show that renal calcium reabsorption and renal membrane abundance of TRPV5 are reduced in Fgf23 knockout mice, similar to what is seen in alphaKlotho knockout mice. We further demonstrate that alphaKlotho neither co-localizes with TRPV5 nor is regulated by FGF23. Rather, apical membrane abundance of TRPV5 in renal distal tubules and thus renal calcium reabsorption are regulated by FGF23, which binds the FGF receptor-alphaKlotho complex and activates a signaling cascade involving ERK1/2, SGK1, and WNK4. Our data thereby identify FGF23, not alphaKlotho, as a calcium-conserving hormone in the kidney. Twit Text FOAVip FGF23 promotes renal calcium reabsorption through the TRPV5 channel ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=24434184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24434184 #FOAvip English Wikipedia <ref>{{Cite pmid|24434184}}</ref> FGF23 promotes renal calcium reabsorption through the TRPV5 channel #MMPMID24434184 Andrukhova O; Smorodchenko A; Egerbacher M; Streicher C; Zeitz U; Goetz R; Shalhoub V; Mohammadi M; Pohl EE; Lanske B; Erben RG EMBO J 2014[Feb]; 33 (3): 229-46 PMID24434184show ga alphaKlotho is thought to activate the epithelial calcium channel Transient Receptor Potential Vanilloid-5 (TRPV5) in distal renal tubules through its putative glucuronidase/sialidase activity, thereby preventing renal calcium loss. However, alphaKlotho also functions as the obligatory co-receptor for fibroblast growth factor-23 (FGF23), a bone-derived phosphaturic hormone. Here, we show that renal calcium reabsorption and renal membrane abundance of TRPV5 are reduced in Fgf23 knockout mice, similar to what is seen in alphaKlotho knockout mice. We further demonstrate that alphaKlotho neither co-localizes with TRPV5 nor is regulated by FGF23. Rather, apical membrane abundance of TRPV5 in renal distal tubules and thus renal calcium reabsorption are regulated by FGF23, which binds the FGF receptor-alphaKlotho complex and activates a signaling cascade involving ERK1/2, SGK1, and WNK4. Our data thereby identify FGF23, not alphaKlotho, as a calcium-conserving hormone in the kidney. |Animals[MESH] |Calcium/*metabolism[MESH] |Cell Membrane/metabolism[MESH] |Fibroblast Growth Factor-23[MESH] |Fibroblast Growth Factors/genetics/*metabolism[MESH] |Glucuronidase[MESH] |Immediate-Early Proteins/metabolism[MESH] |Kidney/*metabolism[MESH] |Klotho Proteins[MESH] |Male[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Protein Serine-Threonine Kinases/metabolism[MESH] |Receptors, Cell Surface/*metabolism[MESH] |Signal Transduction[MESH]FGF23 promotes renal calcium reabsorption through the TRPV5 channel (epmc).pdf DeepDyve Pubget Overpricing