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10.1681/ASN.2013050481 http://scihub22266oqcxt.onion/10.1681/ASN.2013050481 24408873!3968497!24408873     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2014 ; 25 (4): 693-705 Nephropedia Template TP {{tp|p=24408873|t=2014. The regenerative potential of parietal epithelial cells in adult mice |pdf=|usr=}}{{24408873}} gab.com Text The regenerative potential of parietal epithelial cells in adult mice JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24408873 #FOAvip Previously, we showed that some podocytes in juvenile mice are recruited from cells lining Bowman's capsule, suggesting that parietal epithelial cells (PECs) are a progenitor cell population for podocytes. To investigate whether PECs also replenish podocytes in adult mice, PECs were genetically labeled in an irreversible fashion in 5-week-old mice. No significant increase in labeled podocytes was observed, even after 18 months. To accelerate a potential regenerative mechanism, progressive glomerular hypertrophy was induced by progressive partial nephrectomies. Again, no significant podocyte replenishment was observed. Rather, labeled PECs exclusively invaded segments of the tuft affected by glomerulosclerosis, consistent with our previous findings. We next reassessed PEC recruitment in juvenile mice using a different reporter mouse and confirmed significant recruitment of labeled PECs onto the glomerular tuft. Moreover, some labeled cells on Bowman's capsule expressed podocyte markers, and cells on Bowman's capsule were also directly labeled in juvenile podocyte-specific Pod-rtTA transgenic mice. In 6-week-old mice, however, cells on Bowman's capsule no longer expressed podocyte-specific markers. Similarly, in human kidneys, some cells on Bowman's capsule expressed the podocyte marker synaptopodin from 2 weeks to 2 years of age but not at 7 years of age. In summary, podocyte regeneration from PECs could not be detected in aging mice or models of glomerular hypertrophy. We propose that a small fraction of committed podocytes reside on Bowman's capsule close to the vascular stalk and are recruited onto the glomerular tuft during infancy to adolescence in mice and humans. Twit Text FOAVip The regenerative potential of parietal epithelial cells in adult mice ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24408873 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24408873 #FOAvip English Wikipedia <ref>{{Cite pmid|24408873}}</ref> The regenerative potential of parietal epithelial cells in adult mice #MMPMID24408873 Berger K; Schulte K; Boor P; Kuppe C; van Kuppevelt TH; Floege J; Smeets B; Moeller MJ J Am Soc Nephrol 2014[Apr]; 25 (4): 693-705 PMID24408873show ga Previously, we showed that some podocytes in juvenile mice are recruited from cells lining Bowman's capsule, suggesting that parietal epithelial cells (PECs) are a progenitor cell population for podocytes. To investigate whether PECs also replenish podocytes in adult mice, PECs were genetically labeled in an irreversible fashion in 5-week-old mice. No significant increase in labeled podocytes was observed, even after 18 months. To accelerate a potential regenerative mechanism, progressive glomerular hypertrophy was induced by progressive partial nephrectomies. Again, no significant podocyte replenishment was observed. Rather, labeled PECs exclusively invaded segments of the tuft affected by glomerulosclerosis, consistent with our previous findings. We next reassessed PEC recruitment in juvenile mice using a different reporter mouse and confirmed significant recruitment of labeled PECs onto the glomerular tuft. Moreover, some labeled cells on Bowman's capsule expressed podocyte markers, and cells on Bowman's capsule were also directly labeled in juvenile podocyte-specific Pod-rtTA transgenic mice. In 6-week-old mice, however, cells on Bowman's capsule no longer expressed podocyte-specific markers. Similarly, in human kidneys, some cells on Bowman's capsule expressed the podocyte marker synaptopodin from 2 weeks to 2 years of age but not at 7 years of age. In summary, podocyte regeneration from PECs could not be detected in aging mice or models of glomerular hypertrophy. We propose that a small fraction of committed podocytes reside on Bowman's capsule close to the vascular stalk and are recruited onto the glomerular tuft during infancy to adolescence in mice and humans. |Aging/pathology[MESH] |Animals[MESH] |Bowman Capsule/cytology[MESH] |Epithelial Cells/*physiology[MESH] |Glomerulosclerosis, Focal Segmental/pathology[MESH] |Hypertrophy[MESH] |Kidney Glomerulus/pathology[MESH] |Mice[MESH] |Podocytes/*cytology[MESH]The regenerative potential of parietal epithelial cells in adult mice (epmc).pdf DeepDyve Pubget Overpricing