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10.4161/onci.26383

http://scihub22266oqcxt.onion/10.4161/onci.26383
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24404426!3881600!24404426
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suck abstract from ncbi

pmid24404426      Oncoimmunology 2013 ; 2 (11): e26383
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  • Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology #MMPMID24404426
  • Husain Z; Seth P; Sukhatme VP
  • Oncoimmunology 2013[Nov]; 2 (11): e26383 PMID24404426show ga
  • Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progression. Ketogenic diets can deplete tumor-bearing animals from MDSCs and regulatory T cells, thereby improving their immunological profile.
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