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10.1111/1469-0691.12505 http://scihub22266oqcxt.onion/10.1111/1469-0691.12505 24350809!ä!24350809 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Microbiol+Infect 2014 ; 20 (8): O493-500 Nephropedia Template TP {{tp|p=24350809|t=2014. Host immunological response and factors associated with clinical outcome in patients with the novel influenza A H7N9 infection |pdf=|usr=}}{{24350809}} gab.com Text Host immunological response and factors associated with clinical outcome in patients with the novel influenza A H7N9 infection JO: Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=24350809 #FOAvip In March 2013, an influenza outbreak caused by the novel avian-origin H7N9 influenza A virus emerged in eastern China and had caused 43 fatalities by 31 July 2013, although the basis for disease pathogenesis still remains unclear. To assess the immunological and viral factors associated with disease severity, viral RNA and inflammatory cytokines were quantified for 18 H7N9 patients in Shanghai, China. Detailed clinical information was collected and clinical laboratory investigations were performed for all patients. H7N9 infection is characterized by high pharyngeal virus load and frequent detection of viral RNA in blood. High pharyngeal virus load persisted through the first 10 days of antiviral therapy in fatal cases. Genetic characterization of the H7N9 virus revealed an Arg292Lys mutation in the neuraminidase gene associated with oseltamivir-resistance. Pronounced lymphopenia and high chemokine and cytokine levels were observed in H7N9-infected patients, particularly in those where disease was fatal. Serum levels of interleukin-6 (IL-6), IL-8 and macrophage inflammatory protein-1beta in our subjects also correlated positively with pharyngeal virus load. Lymphocyte counts <0.5 x 10(9) cells/L, and serum IL-6 >97 pg/mL, IL-8 >40 pg/mL and C-reactive protein >90 mg/L were identified as being connected with adverse clinical outcome through univariate logistic analysis. Significant survival differences were also observed between patients with serum C-reactive protein <90 mg/L or creatinine <90 mumol/L and those with higher levels. Our data demonstrated that high viral load, and the resulting intense inflammatory responses, played an important role in H7N9 pathogenesis. Though immunomodulatory treatment has potential benefits, the focus of clinical management should be on preventing the intense cytokine response by early diagnosis and effective antiviral treatment. Twit Text FOAVip Host immunological response and factors associated with clinical outcome in patients with the novel influenza A H7N9 infection ????Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=24350809 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24350809 #FOAvip English Wikipedia <ref>{{Cite pmid|24350809}}</ref> Host immunological response and factors associated with clinical outcome in patients with the novel influenza A H7N9 infection #MMPMID24350809 Shen Z; Chen Z; Li X; Xu L; Guan W; Cao Y; Hu Y; Zhang J Clin Microbiol Infect 2014[Aug]; 20 (8): O493-500 PMID24350809show ga In March 2013, an influenza outbreak caused by the novel avian-origin H7N9 influenza A virus emerged in eastern China and had caused 43 fatalities by 31 July 2013, although the basis for disease pathogenesis still remains unclear. To assess the immunological and viral factors associated with disease severity, viral RNA and inflammatory cytokines were quantified for 18 H7N9 patients in Shanghai, China. Detailed clinical information was collected and clinical laboratory investigations were performed for all patients. H7N9 infection is characterized by high pharyngeal virus load and frequent detection of viral RNA in blood. High pharyngeal virus load persisted through the first 10 days of antiviral therapy in fatal cases. Genetic characterization of the H7N9 virus revealed an Arg292Lys mutation in the neuraminidase gene associated with oseltamivir-resistance. Pronounced lymphopenia and high chemokine and cytokine levels were observed in H7N9-infected patients, particularly in those where disease was fatal. Serum levels of interleukin-6 (IL-6), IL-8 and macrophage inflammatory protein-1beta in our subjects also correlated positively with pharyngeal virus load. Lymphocyte counts <0.5 x 10(9) cells/L, and serum IL-6 >97 pg/mL, IL-8 >40 pg/mL and C-reactive protein >90 mg/L were identified as being connected with adverse clinical outcome through univariate logistic analysis. Significant survival differences were also observed between patients with serum C-reactive protein <90 mg/L or creatinine <90 mumol/L and those with higher levels. Our data demonstrated that high viral load, and the resulting intense inflammatory responses, played an important role in H7N9 pathogenesis. Though immunomodulatory treatment has potential benefits, the focus of clinical management should be on preventing the intense cytokine response by early diagnosis and effective antiviral treatment. |*Viral Load[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antiviral Agents/pharmacology[MESH] |Blood/virology[MESH] |C-Reactive Protein/analysis[MESH] |China[MESH] |Cytokines/*blood[MESH] |Drug Resistance, Viral[MESH] |Female[MESH] |Humans[MESH] |Influenza A Virus, H7N9 Subtype/*isolation & purification[MESH] |Influenza, Human/*immunology/*pathology/virology[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Middle Aged[MESH] |Mutation, Missense[MESH] |Neuraminidase/genetics[MESH] |Oseltamivir/pharmacology[MESH] |Pharynx/virology[MESH] |Survival Analysis[MESH]Host immunological response and factors associated with clinical outco(epmc).pdf DeepDyve Pubget Overpricing