Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1371/journal.pone.0082827 http://scihub22266oqcxt.onion/10.1371/journal.pone.0082827 24349374!3859620!24349374     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2013 ; 8 (12): e82827 Nephropedia Template TP {{tp|p=24349374|t=2013. Mipu1, a novel direct target gene, is involved in hypoxia inducible factor 1-mediated cytoprotection |pdf=|usr=}}{{24349374}} gab.com Text Mipu1, a novel direct target gene, is involved in hypoxia inducible factor 1-mediated cytoprotection JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=24349374 #FOAvip Mipu1 (myocardial ischemic preconditioning up-regulated protein 1), recently identified in our lab, is a novel zinc-finger transcription factor which is up-regulated during ischemic preconditioning. However, it is not clear what transcription factor contributes to its inducible expression. In the present study, we reported that HIF-1 regulates the inducible expression of Mipu1 which is involved in the cytoprotection of HIF-1alpha against oxidative stress by inhibiting Bax expression. Our results showed that the inducible expression of Mipu1 was associated with the expression and activation of transcription factor HIF-1 as indicated by cobalt chloride (CoCl2) treatment, HIF-1alpha overexpression and knockdown assays. EMSA and luciferase reporter gene assays showed that HIF-1alpha bound to the hypoxia response element (HRE) within Mipu1 promoter region and promoted its transcription. Moreover, our results revealed that Mipu1 inhibited the expression of Bax, an important pro-apoptosis protein associated with the intrinsic pathway of apoptosis, elevating the cytoprotection of HIF-1 against hydrogen peroxide (H2O2)-mediated injury in H9C2 cells. Our findings implied that Bax may be a potential target gene of transcription factor Mipu1, and provided a novel insight for understanding the cytoprotection of HIF-1 and new clues for further elucidating the mechanisms by which Mipu1 protects cell against pathological stress. Twit Text FOAVip Mipu1, a novel direct target gene, is involved in hypoxia inducible factor 1-mediated cytoprotection ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=24349374 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24349374 #FOAvip English Wikipedia <ref>{{Cite pmid|24349374}}</ref> Mipu1, a novel direct target gene, is involved in hypoxia inducible factor 1-mediated cytoprotection #MMPMID24349374 Wang K; Lei J; Zou J; Xiao H; Chen A; Liu X; Liu Y; Jiang L; Xiao Z; Xiao X PLoS One 2013[]; 8 (12): e82827 PMID24349374show ga Mipu1 (myocardial ischemic preconditioning up-regulated protein 1), recently identified in our lab, is a novel zinc-finger transcription factor which is up-regulated during ischemic preconditioning. However, it is not clear what transcription factor contributes to its inducible expression. In the present study, we reported that HIF-1 regulates the inducible expression of Mipu1 which is involved in the cytoprotection of HIF-1alpha against oxidative stress by inhibiting Bax expression. Our results showed that the inducible expression of Mipu1 was associated with the expression and activation of transcription factor HIF-1 as indicated by cobalt chloride (CoCl2) treatment, HIF-1alpha overexpression and knockdown assays. EMSA and luciferase reporter gene assays showed that HIF-1alpha bound to the hypoxia response element (HRE) within Mipu1 promoter region and promoted its transcription. Moreover, our results revealed that Mipu1 inhibited the expression of Bax, an important pro-apoptosis protein associated with the intrinsic pathway of apoptosis, elevating the cytoprotection of HIF-1 against hydrogen peroxide (H2O2)-mediated injury in H9C2 cells. Our findings implied that Bax may be a potential target gene of transcription factor Mipu1, and provided a novel insight for understanding the cytoprotection of HIF-1 and new clues for further elucidating the mechanisms by which Mipu1 protects cell against pathological stress. |Animals[MESH] |Cell Line[MESH] |Cobalt/pharmacology[MESH] |Gene Expression[MESH] |Gene Expression Regulation/drug effects[MESH] |Genes, Reporter[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism[MESH] |Hypoxia/*metabolism/*microbiology[MESH] |Nuclear Proteins/*genetics/metabolism[MESH] |Oxidative Stress[MESH] |Promoter Regions, Genetic[MESH] |Protein Binding[MESH] |RNA Interference[MESH] |Rats[MESH] |Repressor Proteins/*genetics/metabolism[MESH] |Transcriptional Activation[MESH]Mipu1, a novel direct target gene, is involved in hypoxia inducible fa(epmc).pdf DeepDyve Pubget Overpricing