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suck abstract from ncbi


10.1177/0961203313513509

http://scihub22266oqcxt.onion/10.1177/0961203313513509
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24285096!ä!24285096

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suck abstract from ncbi


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pmid24285096      Lupus 2014 ; 23 (1): 75-80
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  • Collapsing glomerulopathy in collagen vascular-like disease #MMPMID24285096
  • Nasr R; Johns C; Gertner E
  • Lupus 2014[]; 23 (1): 75-80 PMID24285096show ga
  • OBJECTIVE: Collapsing glomerulopathy (CG) is a podocytopathy that is usually associated with human immunodeficiency virus (HIV) and parvovirus B19 infections. CG has been reported in association with definite collagen vascular diseases, mainly systemic lupus erythematosus (SLE). There are a few case reports in the nephrology literature of patients with CG and marked serological abnormalities who do not have sufficient clinical findings to diagnose definite collagen vascular disease. We wish to expand the spectrum of rheumatologic disease that accompanies CG. We describe four patients with CG and collagen vascular-like disease and compare these with 14 similar cases reported in the medical literature. METHODS: Case reports of four new patients with CG and collagen vascular-like disease are presented. We performed a systematic literature review to find all other cases and construct a profile of patients with CG and collagen vascular-like disease. RESULTS: All patients had a similar mode of presentation with severe nephrotic range proteinuria and renal insufficiency resistant to steroids and usual immunomodulatory therapy. All patients had positive antinuclear antibodies (ANA) as well as other marked serological abnormalities but few if any clinical findings that would allow for a definitive diagnosis of a specific collagen vascular disease. Almost all patients became dialysis dependent. Mycophenolate mofetil (MMF) may possibly be a therapeutic option. CONCLUSION: Rheumatologists may be asked to consult on patients with severe proteinuria and renal insufficiency in the presence of marked serological abnormalities but few clinical symptoms and should be aware of this podocytopathy.
  • |Adult[MESH]
  • |Collagen Diseases/*complications[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Kidney Diseases/*etiology[MESH]
  • |Male[MESH]


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