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2426951Malignantfibroushistiocytoma.Expressionofmonocyte/macrophagedifferentiationantigensdetectedwithmonoclonalantibodies.!1888297!2426951
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pmid2426951      Am+J+Pathol 1986 ; 124 (2): 303-9
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  • Malignant fibrous histiocytoma Expression of monocyte/macrophage differentiation antigens detected with monoclonal antibodies #MMPMID2426951
  • Strauchen JA; Dimitriu-Bona A
  • Am J Pathol 1986[Aug]; 124 (2): 303-9 PMID2426951show ga
  • Monoclonal antibodies were used in an investigation of the histogenesis of malignant fibrous histiocytoma (MFH), a neoplasm with morphologic features of both fibroblastic and histiocytic differentiation. In 4 cases of MFH studied, the tumor cells were found to react uniformly with antibodies to determinants expressed on monocyte macrophages (T-200, Ia, MoS-1, MoS-39, MoR-17). Both spindle and histiocyte-like tumor cells expressed these markers. In contrast, in 8 non-MFH soft tissue tumors, tumor cell reactivity was not observed. The reactivity of the spindle cells of MFH for determinants of monocyte/macrophages favors their origin from tissue histiocytes (facultative fibroblasts). The results support the view that MFH is a tumor of the mononuclear phagocyte system.
  • |*Antigens, Differentiation[MESH]
  • |Antibodies, Monoclonal/*immunology[MESH]
  • |Antigens, Neoplasm/analysis/*immunology[MESH]
  • |Antigens, Surface/analysis/*immunology[MESH]
  • |Histiocytoma, Benign Fibrous/*immunology[MESH]
  • |Humans[MESH]
  • |In Vitro Techniques[MESH]
  • |Soft Tissue Neoplasms/*immunology[MESH]


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