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http://scihub22266oqcxt.onion/ 24195363!ä!24195363 Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538 Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538       Sheng+Wu+Gong+Cheng+Xue+Bao 2013 ; 29 (7): 965-73 Nephropedia Template TP {{tp|p=24195363|t=2013. Regulatory effect of 11 kDa protein of parvovirus B19 on NF-kappaB pathway in Hela cells |pdf=|usr=}}{{24195363}} gab.com Text Regulatory effect of 11 kDa protein of parvovirus B19 on NF-kappaB pathway in Hela cells JO: Sheng Wu Gong Cheng Xue Bao http://www.kidney.de/pget.php?&tw=1&pmid=24195363 #FOAvip The 11 kDa protein, a small nonstructural protein of parvovirus B19, may play important roles in viral replication cycle. To investigate the effect of 11 kDa protein on the NF-kappaB signaling pathway, we first prepared the poly-antiserum using GST-11 kDa fusion protein purified via prokaryotic expression system, and demonstrated that the 11 kDa protein mainly localized in cytoplasm when expressed in Hela cells. Meanwhile, luciferase activity assay and Western blotting assay showed that 11 kDa up-regulated the transcriptional activity of NF-kappaB and induced the degradation of IkappaB-alpha in Hela cells. Moreover, the 11 kDa protein activated the IL6 promoter, which is probably through the NF-kappaB pathway. Taken together, these results suggested that 11 kDa protein may contribute to activating inflammatory factors through participating in the cell signaling pathway. Twit Text FOAVip Regulatory effect of 11 kDa protein of parvovirus B19 on NF-kappaB pathway in Hela cells ????Sheng Wu Gong Cheng Xue Bao http://www.kidney.de/pget.php?&tw=1&pmid=24195363 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24195363 #FOAvip English Wikipedia <ref>{{Cite pmid|24195363}}</ref> Regulatory effect of 11 kDa protein of parvovirus B19 on NF-kappaB pathway in Hela cells #MMPMID24195363 Dong Y; Huang Y; Peng J; Li Y Sheng Wu Gong Cheng Xue Bao 2013[Jul]; 29 (7): 965-73 PMID24195363show ga The 11 kDa protein, a small nonstructural protein of parvovirus B19, may play important roles in viral replication cycle. To investigate the effect of 11 kDa protein on the NF-kappaB signaling pathway, we first prepared the poly-antiserum using GST-11 kDa fusion protein purified via prokaryotic expression system, and demonstrated that the 11 kDa protein mainly localized in cytoplasm when expressed in Hela cells. Meanwhile, luciferase activity assay and Western blotting assay showed that 11 kDa up-regulated the transcriptional activity of NF-kappaB and induced the degradation of IkappaB-alpha in Hela cells. Moreover, the 11 kDa protein activated the IL6 promoter, which is probably through the NF-kappaB pathway. Taken together, these results suggested that 11 kDa protein may contribute to activating inflammatory factors through participating in the cell signaling pathway. |*Signal Transduction[MESH] |HeLa Cells[MESH] |Humans[MESH] |I-kappa B Proteins/*metabolism[MESH] |NF-KappaB Inhibitor alpha[MESH] |NF-kappa B/*metabolism[MESH] |Parvovirus B19, Human[MESH] |Promoter Regions, Genetic[MESH] |Transcriptional Activation[MESH] Regulatory effect of 11 kDa protein of parvovirus B19 on NF-kappaB pa(epmc).pdf DeepDyve Pubget Overpricing