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Pickering MC; D'Agati VD; Nester CM; Smith RJ; Haas M; Appel GB; Alpers CE; Bajema IM; Bedrosian C; Braun M; Doyle M; Fakhouri F; Fervenza FC; Fogo AB; Fremeaux-Bacchi V; Gale DP; Goicoechea de Jorge E; Griffin G; Harris CL; Holers VM; Johnson S; Lavin PJ; Medjeral-Thomas N; Paul Morgan B; Nast CC; Noel LH; Peters DK; Rodriguez de Cordoba S; Servais A; Sethi S; Song WC; Tamburini P; Thurman JM; Zavros M; Cook HT
Kidney Int 2013[Dec]; 84 (6): 1079-89 PMID24172683show ga
C3 glomerulopathy is a recently introduced pathological entity whose original definition was glomerular pathology characterized by C3 accumulation with absent or scanty immunoglobulin deposition. In August 2012, an invited group of experts (comprising the authors of this document) in renal pathology, nephrology, complement biology, and complement therapeutics met to discuss C3 glomerulopathy in the first C3 Glomerulopathy Meeting. The objectives were to reach a consensus on: the definition of C3 glomerulopathy, appropriate complement investigations that should be performed in these patients, and how complement therapeutics should be explored in the condition. This meeting report represents the current consensus view of the group.