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10.1111/adb.12087 http://scihub22266oqcxt.onion/10.1111/adb.12087 24118405/?report=reader!3997615!24118405     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Addict+Biol 2015 ; 20 (1): 143-7 Nephropedia Template TP {{tp|p=24118405|t=2015. Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz s role in ethanol withdrawal and support its role in voluntary ethanol consumption |pdf=|usr=}}{{24118405}} gab.com Text Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz s role in ethanol withdrawal and support its role in voluntary ethanol consumption JO: Addict Biol http://www.kidney.de/pget.php?&tw=1&pmid=24118405 #FOAvip Association studies implicate multiple PDZ domain protein (MPDZ/MUPP1) sequence and/or expression in risk for alcoholism in humans and ethanol withdrawal (EW) in mice, but confirmation has been hindered by the dearth of targeted genetic models. We report the creation of transgenic (MPDZ-TG) and knockout heterozygote (Mpdz(+/-) ) mice, with increased (2.9-fold) and decreased (53%) target expression, respectively. Both models differ in EW compared with wild-type littermates (P </= 0.03), providing compelling evidence for an inverse relationship between Mpdz expression and EW severity. Additionally, ethanol consumption is reduced up to 18% (P = 0.006) in Mpdz(+/-) , providing the first evidence implicating Mpdz in ethanol self-administration. Twit Text FOAVip Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz s role in ethanol withdrawal and support its role in voluntary ethanol consumption ????Addict Biol http://www.kidney.de/pget.php?&tw=1&pmid=24118405 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24118405 #FOAvip English Wikipedia <ref>{{Cite pmid|24118405}}</ref> Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz s role in ethanol withdrawal and support its role in voluntary ethanol consumption #MMPMID24118405 Milner LC; Shirley RL; Kozell LB; Walter NA; Kruse LC; Komiyama NH; Grant SG; Buck KJ Addict Biol 2015[Jan]; 20 (1): 143-7 PMID24118405show ga Association studies implicate multiple PDZ domain protein (MPDZ/MUPP1) sequence and/or expression in risk for alcoholism in humans and ethanol withdrawal (EW) in mice, but confirmation has been hindered by the dearth of targeted genetic models. We report the creation of transgenic (MPDZ-TG) and knockout heterozygote (Mpdz(+/-) ) mice, with increased (2.9-fold) and decreased (53%) target expression, respectively. Both models differ in EW compared with wild-type littermates (P |Alcohol Drinking/*genetics[MESH] |Alcohol Withdrawal Seizures/etiology/*genetics[MESH] |Animals[MESH] |Carrier Proteins/*genetics[MESH] |Central Nervous System Depressants/*adverse effects[MESH] |Ethanol/*adverse effects[MESH] |Gene Knockdown Techniques[MESH] |Membrane Proteins[MESH] |Mice[MESH] |Mice, Transgenic[MESH]Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz s role i(epmc).pdf DeepDyve Pubget Overpricing