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10.1097/PAP.0b013e3182a92d0d http://scihub22266oqcxt.onion/10.1097/PAP.0b013e3182a92d0d 24113309/?report=reader!6637949!24113309     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Anat+Pathol 2013 ; 20 (6): 387-97 Nephropedia Template TP {{tp|p=24113309|t=2013. Classification of rhabdomyosarcoma and its molecular basis |pdf=|usr=}}{{24113309}} gab.com Text Classification of rhabdomyosarcoma and its molecular basis JO: Adv Anat Pathol http://www.kidney.de/pget.php?&tw=1&pmid=24113309 #FOAvip Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, has traditionally been classified into embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS) for pediatric oncology practice. This review outlines the historical development of classification of childhood RMS and the challenges that have been associated with it, particularly problems with the diagnosis of "solid variant" ARMS and its distinction from ERMS. In addition to differences in clinical presentation and outcome, a number of genetic features underpin separation of ERMS from ARMS. Genetic differences associated with RMS subclassification include the presence of reciprocal translocations and their associated fusions in ARMS, amplification of genes in ARMS and its fusion subsets, chromosomal losses and gains that mostly occur in ERMS, and allelic losses and mutations usually associated with ERMS. Chimeric proteins encoded in most ARMS from the fusion of PAX3 or PAX7 with FOXO1 are expressed, result in a distinct pattern of downstream protein expression, and appear to be the proximate cause of the bad outcome associated with this subtype. A sizeable minority of ARMS lacks these fusions and shares the clinical and biological features of ERMS. A battery of immunohistochemical tests may prove useful in separating ERMS from ARMS and fusion-positive ARMS from fusion-negative ARMS. Because of limitation of predicting outcome solely based on histologic classification, treatment protocols will begin to utilize fusion testing for stratification of affected patients into low-risk, intermediate-risk, and high-risk groups. Twit Text FOAVip Classification of rhabdomyosarcoma and its molecular basis ????Adv Anat Pathol http://www.kidney.de/pget.php?&tw=1&pmid=24113309 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24113309 #FOAvip English Wikipedia <ref>{{Cite pmid|24113309}}</ref> Classification of rhabdomyosarcoma and its molecular basis #MMPMID24113309 Parham DM; Barr FG Adv Anat Pathol 2013[Nov]; 20 (6): 387-97 PMID24113309show ga Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, has traditionally been classified into embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS) for pediatric oncology practice. This review outlines the historical development of classification of childhood RMS and the challenges that have been associated with it, particularly problems with the diagnosis of "solid variant" ARMS and its distinction from ERMS. In addition to differences in clinical presentation and outcome, a number of genetic features underpin separation of ERMS from ARMS. Genetic differences associated with RMS subclassification include the presence of reciprocal translocations and their associated fusions in ARMS, amplification of genes in ARMS and its fusion subsets, chromosomal losses and gains that mostly occur in ERMS, and allelic losses and mutations usually associated with ERMS. Chimeric proteins encoded in most ARMS from the fusion of PAX3 or PAX7 with FOXO1 are expressed, result in a distinct pattern of downstream protein expression, and appear to be the proximate cause of the bad outcome associated with this subtype. A sizeable minority of ARMS lacks these fusions and shares the clinical and biological features of ERMS. A battery of immunohistochemical tests may prove useful in separating ERMS from ARMS and fusion-positive ARMS from fusion-negative ARMS. Because of limitation of predicting outcome solely based on histologic classification, treatment protocols will begin to utilize fusion testing for stratification of affected patients into low-risk, intermediate-risk, and high-risk groups. |Child[MESH] |Forkhead Box Protein O1[MESH] |Forkhead Transcription Factors/genetics[MESH] |Humans[MESH] |Oncogene Proteins, Fusion/*genetics[MESH] |PAX3 Transcription Factor[MESH] |PAX7 Transcription Factor/genetics[MESH] |Paired Box Transcription Factors/genetics[MESH] |Prognosis[MESH] |Rhabdomyosarcoma, Alveolar/*classification/genetics/pathology[MESH] |Rhabdomyosarcoma, Embryonal/*classification/genetics/pathology[MESH]Classification of rhabdomyosarcoma and its molecular basis (epmc).pdf DeepDyve Pubget Overpricing