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10.1681/ASN.2013040376 http://scihub22266oqcxt.onion/10.1681/ASN.2013040376 24071005!3871778!24071005     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2014 ; 25 (1): 129-41 Nephropedia Template TP {{tp|p=24071005|t=2014. Origin of parietal podocytes in atubular glomeruli mapped by lineage tracing |pdf=|usr=}}{{24071005}} gab.com Text Origin of parietal podocytes in atubular glomeruli mapped by lineage tracing JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24071005 #FOAvip Parietal podocytes are fully differentiated podocytes lining Bowman's capsule where normally only parietal epithelial cells (PECs) are found. Parietal podocytes form throughout life and are regularly observed in human biopsies, particularly in atubular glomeruli of diseased kidneys; however, the origin of parietal podocytes is unresolved. To assess the capacity of PECs to transdifferentiate into parietal podocytes, we developed and characterized a novel method for creating atubular glomeruli by electrocoagulation of the renal cortex in mice. Electrocoagulation produced multiple atubular glomeruli containing PECs as well as parietal podocytes that projected from the vascular pole and lined Bowman's capsule. Notably, induction of cell death was evident in some PECs. In contrast, Bowman's capsules of control animals and normal glomeruli of electrocoagulated kidneys rarely contained podocytes. PECs and podocytes were traced by inducible and irreversible genetic tagging using triple transgenic mice (PEC- or Pod-rtTA/LC1/R26R). Examination of serial cryosections indicated that visceral podocytes migrated onto Bowman's capsule via the vascular stalk; direct transdifferentiation from PECs to podocytes was not observed. Similar results were obtained in a unilateral ureter obstruction model and in human diseased kidney biopsies, in which overlap of PEC- or podocyte-specific antibody staining indicative of gradual differentiation did not occur. These results suggest that induction of atubular glomeruli leads to ablation of PECs and subsequent migration of visceral podocytes onto Bowman's capsule, rather than transdifferentiation from PECs to parietal podocytes. Twit Text FOAVip Origin of parietal podocytes in atubular glomeruli mapped by lineage tracing ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24071005 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24071005 #FOAvip English Wikipedia <ref>{{Cite pmid|24071005}}</ref> Origin of parietal podocytes in atubular glomeruli mapped by lineage tracing #MMPMID24071005 Schulte K; Berger K; Boor P; Jirak P; Gelman IH; Arkill KP; Neal CR; Kriz W; Floege J; Smeets B; Moeller MJ J Am Soc Nephrol 2014[Jan]; 25 (1): 129-41 PMID24071005show ga Parietal podocytes are fully differentiated podocytes lining Bowman's capsule where normally only parietal epithelial cells (PECs) are found. Parietal podocytes form throughout life and are regularly observed in human biopsies, particularly in atubular glomeruli of diseased kidneys; however, the origin of parietal podocytes is unresolved. To assess the capacity of PECs to transdifferentiate into parietal podocytes, we developed and characterized a novel method for creating atubular glomeruli by electrocoagulation of the renal cortex in mice. Electrocoagulation produced multiple atubular glomeruli containing PECs as well as parietal podocytes that projected from the vascular pole and lined Bowman's capsule. Notably, induction of cell death was evident in some PECs. In contrast, Bowman's capsules of control animals and normal glomeruli of electrocoagulated kidneys rarely contained podocytes. PECs and podocytes were traced by inducible and irreversible genetic tagging using triple transgenic mice (PEC- or Pod-rtTA/LC1/R26R). Examination of serial cryosections indicated that visceral podocytes migrated onto Bowman's capsule via the vascular stalk; direct transdifferentiation from PECs to podocytes was not observed. Similar results were obtained in a unilateral ureter obstruction model and in human diseased kidney biopsies, in which overlap of PEC- or podocyte-specific antibody staining indicative of gradual differentiation did not occur. These results suggest that induction of atubular glomeruli leads to ablation of PECs and subsequent migration of visceral podocytes onto Bowman's capsule, rather than transdifferentiation from PECs to parietal podocytes. |Animals[MESH] |Bowman Capsule/cytology[MESH] |Cell Lineage[MESH] |Cell Movement[MESH] |Cell Transdifferentiation[MESH] |Disease Models, Animal[MESH] |Electrocoagulation[MESH] |Epithelial Cells/cytology[MESH] |Female[MESH] |Humans[MESH] |Kidney Glomerulus/*cytology/surgery[MESH] |Male[MESH] |Mice[MESH] |Mice, 129 Strain[MESH] |Mice, Inbred C57BL[MESH] |Mice, Transgenic[MESH] |Models, Biological[MESH] |Podocytes/*cytology/metabolism[MESH]Origin of parietal podocytes in atubular glomeruli mapped by lineage t(epmc).pdf DeepDyve Pubget Overpricing