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10.1176/appi.ajp.2013.13020185 http://scihub22266oqcxt.onion/10.1176/appi.ajp.2013.13020185 24030475/?report=reader!4091043!24030475     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Psychiatry 2013 ; 170 (11): 1249-62 Nephropedia Template TP {{tp|p=24030475|t=2013. The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders |pdf=|usr=}}{{24030475}} gab.com Text The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders JO: Am J Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=24030475 #FOAvip OBJECTIVE: The risk-benefit profile of antidepressant medications in bipolar disorder is controversial. When conclusive evidence is lacking, expert consensus can guide treatment decisions. The International Society for Bipolar Disorders (ISBD) convened a task force to seek consensus recommendations on the use of antidepressants in bipolar disorders. METHOD: An expert task force iteratively developed consensus through serial consensus-based revisions using the Delphi method. Initial survey items were based on systematic review of the literature. Subsequent surveys included new or reworded items and items that needed to be rerated. This process resulted in the final ISBD Task Force clinical recommendations on antidepressant use in bipolar disorder. RESULTS: There is striking incongruity between the wide use of and the weak evidence base for the efficacy and safety of antidepressant drugs in bipolar disorder. Few well-designed, long-term trials of prophylactic benefits have been conducted, and there is insufficient evidence for treatment benefits with antidepressants combined with mood stabilizers. A major concern is the risk for mood switch to hypomania, mania, and mixed states. Integrating the evidence and the experience of the task force members, a consensus was reached on 12 statements on the use of antidepressants in bipolar disorder. CONCLUSIONS: Because of limited data, the task force could not make broad statements endorsing antidepressant use but acknowledged that individual bipolar patients may benefit from antidepressants. Regarding safety, serotonin reuptake inhibitors and bupropion may have lower rates of manic switch than tricyclic and tetracyclic antidepressants and norepinephrine-serotonin reuptake inhibitors. The frequency and severity of antidepressant-associated mood elevations appear to be greater in bipolar I than bipolar II disorder. Hence, in bipolar I patients antidepressants should be prescribed only as an adjunct to mood-stabilizing medications. Twit Text FOAVip The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders ????Am J Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=24030475 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24030475 #FOAvip English Wikipedia <ref>{{Cite pmid|24030475}}</ref> The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders #MMPMID24030475 Pacchiarotti I; Bond DJ; Baldessarini RJ; Nolen WA; Grunze H; Licht RW; Post RM; Berk M; Goodwin GM; Sachs GS; Tondo L; Findling RL; Youngstrom EA; Tohen M; Undurraga J; Gonzalez-Pinto A; Goldberg JF; Yildiz A; Altshuler LL; Calabrese JR; Mitchell PB; Thase ME; Koukopoulos A; Colom F; Frye MA; Malhi GS; Fountoulakis KN; Vazquez G; Perlis RH; Ketter TA; Cassidy F; Akiskal H; Azorin JM; Valenti M; Mazzei DH; Lafer B; Kato T; Mazzarini L; Martinez-Aran A; Parker G; Souery D; Ozerdem A; McElroy SL; Girardi P; Bauer M; Yatham LN; Zarate CA; Nierenberg AA; Birmaher B; Kanba S; El-Mallakh RS; Serretti A; Rihmer Z; Young AH; Kotzalidis GD; MacQueen GM; Bowden CL; Ghaemi SN; Lopez-Jaramillo C; Rybakowski J; Ha K; Perugi G; Kasper S; Amsterdam JD; Hirschfeld RM; Kapczinski F; Vieta E Am J Psychiatry 2013[Nov]; 170 (11): 1249-62 PMID24030475show ga OBJECTIVE: The risk-benefit profile of antidepressant medications in bipolar disorder is controversial. When conclusive evidence is lacking, expert consensus can guide treatment decisions. The International Society for Bipolar Disorders (ISBD) convened a task force to seek consensus recommendations on the use of antidepressants in bipolar disorders. METHOD: An expert task force iteratively developed consensus through serial consensus-based revisions using the Delphi method. Initial survey items were based on systematic review of the literature. Subsequent surveys included new or reworded items and items that needed to be rerated. This process resulted in the final ISBD Task Force clinical recommendations on antidepressant use in bipolar disorder. RESULTS: There is striking incongruity between the wide use of and the weak evidence base for the efficacy and safety of antidepressant drugs in bipolar disorder. Few well-designed, long-term trials of prophylactic benefits have been conducted, and there is insufficient evidence for treatment benefits with antidepressants combined with mood stabilizers. A major concern is the risk for mood switch to hypomania, mania, and mixed states. Integrating the evidence and the experience of the task force members, a consensus was reached on 12 statements on the use of antidepressants in bipolar disorder. CONCLUSIONS: Because of limited data, the task force could not make broad statements endorsing antidepressant use but acknowledged that individual bipolar patients may benefit from antidepressants. Regarding safety, serotonin reuptake inhibitors and bupropion may have lower rates of manic switch than tricyclic and tetracyclic antidepressants and norepinephrine-serotonin reuptake inhibitors. The frequency and severity of antidepressant-associated mood elevations appear to be greater in bipolar I than bipolar II disorder. Hence, in bipolar I patients antidepressants should be prescribed only as an adjunct to mood-stabilizing medications. |Advisory Committees[MESH] |Affect/drug effects[MESH] |Antidepressive Agents/adverse effects/*therapeutic use[MESH] |Bipolar Disorder/*drug therapy[MESH] |Consensus[MESH] |Delphi Technique[MESH] |Humans[MESH] |Suicide Prevention[MESH] |Suicide/psychology[MESH]The International Society for Bipolar Disorders (ISBD) task force repo(epmc).pdf DeepDyve Pubget Overpricing