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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/emmm.201201584 http://scihub22266oqcxt.onion/10.1002/emmm.201201584 23996934!3799579!23996934     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Mol+Med 2013 ; 5 (10): 1556-68 Nephropedia Template TP {{tp|p=23996934|t=2013. Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease |pdf=|usr=}}{{23996934}} gab.com Text Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=23996934 #FOAvip Identification of tissue-specific renal stem/progenitor cells with nephrogenic potential is a critical step in developing cell-based therapies for renal disease. In the human kidney, stem/progenitor cells are induced into the nephrogenic pathway to form nephrons until the 34 week of gestation, and no equivalent cell types can be traced in the adult kidney. Human nephron progenitor cells (hNPCs) have yet to be isolated. Here we show that growth of human foetal kidneys in serum-free defined conditions and prospective isolation of NCAM1(+) cells selects for nephron lineage that includes the SIX2-positive cap mesenchyme cells identifying a mitotically active population with in vitro clonogenic and stem/progenitor properties. After transplantation in the chick embryo, these cells-but not differentiated counterparts-efficiently formed various nephron tubule types. hNPCs engrafted and integrated in diseased murine kidneys and treatment of renal failure in the 5/6 nephrectomy kidney injury model had beneficial effects on renal function halting disease progression. These findings constitute the first definition of an intrinsic nephron precursor population, with major potential for cell-based therapeutic strategies and modelling of kidney disease. Twit Text FOAVip Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=23996934 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23996934 #FOAvip English Wikipedia <ref>{{Cite pmid|23996934}}</ref> Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease #MMPMID23996934 Harari-Steinberg O; Metsuyanim S; Omer D; Gnatek Y; Gershon R; Pri-Chen S; Ozdemir DD; Lerenthal Y; Noiman T; Ben-Hur H; Vaknin Z; Schneider DF; Aronow BJ; Goldstein RS; Hohenstein P; Dekel B EMBO Mol Med 2013[Oct]; 5 (10): 1556-68 PMID23996934show ga Identification of tissue-specific renal stem/progenitor cells with nephrogenic potential is a critical step in developing cell-based therapies for renal disease. In the human kidney, stem/progenitor cells are induced into the nephrogenic pathway to form nephrons until the 34 week of gestation, and no equivalent cell types can be traced in the adult kidney. Human nephron progenitor cells (hNPCs) have yet to be isolated. Here we show that growth of human foetal kidneys in serum-free defined conditions and prospective isolation of NCAM1(+) cells selects for nephron lineage that includes the SIX2-positive cap mesenchyme cells identifying a mitotically active population with in vitro clonogenic and stem/progenitor properties. After transplantation in the chick embryo, these cells-but not differentiated counterparts-efficiently formed various nephron tubule types. hNPCs engrafted and integrated in diseased murine kidneys and treatment of renal failure in the 5/6 nephrectomy kidney injury model had beneficial effects on renal function halting disease progression. These findings constitute the first definition of an intrinsic nephron precursor population, with major potential for cell-based therapeutic strategies and modelling of kidney disease. |*Stem Cell Transplantation[MESH] |Animals[MESH] |CD56 Antigen/metabolism[MESH] |Cells, Cultured[MESH] |Chick Embryo[MESH] |Chickens[MESH] |Chorioallantoic Membrane/metabolism/pathology[MESH] |Embryo, Mammalian/cytology[MESH] |Female[MESH] |Homeodomain Proteins/metabolism[MESH] |Humans[MESH] |Kidney Tubules/pathology[MESH] |Mesenchymal Stem Cells/cytology/metabolism[MESH] |Mice[MESH] |Mice, Inbred NOD[MESH] |Mice, SCID[MESH] |Nephrons/*cytology[MESH] |Nerve Tissue Proteins/metabolism[MESH] |Renal Insufficiency, Chronic/*surgery[MESH]Identification of human nephron progenitors capable of generation of k(epmc).pdf DeepDyve Pubget Overpricing