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10.1002/anie.201302588 http://scihub22266oqcxt.onion/10.1002/anie.201302588 23963798!ä!23963798 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Angew+Chem+Int+Ed+Engl 2013 ; 52 (36): 9442-62 Nephropedia Template TP {{tp|p=23963798|t=2013. The chemistry and biology of soluble guanylate cyclase stimulators and activators |pdf=|usr=}}{{23963798}} gab.com Text The chemistry and biology of soluble guanylate cyclase stimulators and activators JO: Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=23963798 #FOAvip The vasodilatory properties of nitric oxide (NO) have been utilized in pharmacotherapy for more than 130 years. Still today, NO-donor drugs are important in the management of cardiovascular diseases. However, inhaled NO or drugs releasing NO and organic nitrates are associated with noteworthy therapeutic shortcomings, including resistance to NO in some disease states, the development of tolerance during long-term treatment, and nonspecific effects, such as post-translational modification of proteins. The beneficial actions of NO are mediated by stimulation of soluble guanylate cyclase (sGC), a heme-containing enzyme which produces the intracellular signaling molecule cyclic guanosine monophosphate (cGMP). Recently, two classes of compounds have been discovered that amplify the function of sGC in a NO-independent manner, the so-called sGC stimulators and sGC activators. The most advanced drug, the sGC stimulator riociguat, has successfully undergone Phase III clinical trials for different forms of pulmonary hypertension. Twit Text FOAVip The chemistry and biology of soluble guanylate cyclase stimulators and activators ????Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=23963798 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23963798 #FOAvip English Wikipedia <ref>{{Cite pmid|23963798}}</ref> The chemistry and biology of soluble guanylate cyclase stimulators and activators #MMPMID23963798 Follmann M; Griebenow N; Hahn MG; Hartung I; Mais FJ; Mittendorf J; Schafer M; Schirok H; Stasch JP; Stoll F; Straub A Angew Chem Int Ed Engl 2013[Sep]; 52 (36): 9442-62 PMID23963798show ga The vasodilatory properties of nitric oxide (NO) have been utilized in pharmacotherapy for more than 130 years. Still today, NO-donor drugs are important in the management of cardiovascular diseases. However, inhaled NO or drugs releasing NO and organic nitrates are associated with noteworthy therapeutic shortcomings, including resistance to NO in some disease states, the development of tolerance during long-term treatment, and nonspecific effects, such as post-translational modification of proteins. The beneficial actions of NO are mediated by stimulation of soluble guanylate cyclase (sGC), a heme-containing enzyme which produces the intracellular signaling molecule cyclic guanosine monophosphate (cGMP). Recently, two classes of compounds have been discovered that amplify the function of sGC in a NO-independent manner, the so-called sGC stimulators and sGC activators. The most advanced drug, the sGC stimulator riociguat, has successfully undergone Phase III clinical trials for different forms of pulmonary hypertension. |Drug Discovery[MESH] |Enzyme Activation/drug effects[MESH] |Enzyme Activators/*pharmacology[MESH] |Guanylate Cyclase/*metabolism[MESH] |Humans[MESH] |Pyrazoles/chemistry/pharmacology[MESH] |Pyrimidines/chemistry/pharmacology[MESH] |Receptors, Cytoplasmic and Nuclear/*metabolism[MESH] |Signal Transduction[MESH]The chemistry and biology of soluble guanylate cyclase stimulators and(epmc).pdf DeepDyve Pubget Overpricing