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10.1016/j.bbrc.2013.08.006 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2013.08.006 23939047!ä!23939047 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2013 ; 438 (4): 619-23 Nephropedia Template TP {{tp|p=23939047|t=2013. Borna disease virus nucleoprotein inhibits type I interferon induction through the interferon regulatory factor 7 pathway |pdf=|usr=}}{{23939047}} gab.com Text Borna disease virus nucleoprotein inhibits type I interferon induction through the interferon regulatory factor 7 pathway JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=23939047 #FOAvip The expression of type I interferon (IFN) is one of the most potent innate defences against viral infection in higher vertebrates. Borna disease virus (BDV) establishes persistent, noncytolytic infections in animals and in cultured cells. Early studies have shown that the BDV phosphoprotein can inhibit the activation of type I IFN through the TBK1-IRF3 pathway. The function of the BDV nucleoprotein in the inhibition of IFN activity is not yet clear. In this study, we demonstrated IRF7 activation and increased IFN-alpha/beta expression in a BDV-persistently infected human oligodendroglia cell line following RNA interference-mediated BDV nucleoprotein silencing. Furthermore, we showed that BDV nucleoprotein prevented the nuclear localisation of IRF7 and inhibited endogenous IFN induction by poly(I:C), coxsackie virus B3 and IFN-beta. Our findings provide evidence for a previously undescribed mechanism by which the BDV nucleoprotein inhibits type I IFN expression by interfering with the IRF7 pathway. Twit Text FOAVip Borna disease virus nucleoprotein inhibits type I interferon induction through the interferon regulatory factor 7 pathway ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=23939047 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23939047 #FOAvip English Wikipedia <ref>{{Cite pmid|23939047}}</ref> Borna disease virus nucleoprotein inhibits type I interferon induction through the interferon regulatory factor 7 pathway #MMPMID23939047 Song W; Kao W; Zhai A; Qian J; Li Y; Zhang Q; Zhao H; Hu Y; Li H; Zhang F Biochem Biophys Res Commun 2013[Sep]; 438 (4): 619-23 PMID23939047show ga The expression of type I interferon (IFN) is one of the most potent innate defences against viral infection in higher vertebrates. Borna disease virus (BDV) establishes persistent, noncytolytic infections in animals and in cultured cells. Early studies have shown that the BDV phosphoprotein can inhibit the activation of type I IFN through the TBK1-IRF3 pathway. The function of the BDV nucleoprotein in the inhibition of IFN activity is not yet clear. In this study, we demonstrated IRF7 activation and increased IFN-alpha/beta expression in a BDV-persistently infected human oligodendroglia cell line following RNA interference-mediated BDV nucleoprotein silencing. Furthermore, we showed that BDV nucleoprotein prevented the nuclear localisation of IRF7 and inhibited endogenous IFN induction by poly(I:C), coxsackie virus B3 and IFN-beta. Our findings provide evidence for a previously undescribed mechanism by which the BDV nucleoprotein inhibits type I IFN expression by interfering with the IRF7 pathway. |*Host-Pathogen Interactions[MESH] |Borna Disease/*genetics/metabolism/virology[MESH] |Borna disease virus/*physiology[MESH] |Cell Line[MESH] |Down-Regulation[MESH] |Humans[MESH] |Interferon Regulatory Factor-7/analysis/*metabolism[MESH] |Interferon Type I/*genetics[MESH] |Nucleoproteins/*metabolism[MESH] |Signal Transduction[MESH]Borna disease virus nucleoprotein inhibits type I interferon induction(epmc).pdf DeepDyve Pubget Overpricing