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10.18632/aging.100577 http://scihub22266oqcxt.onion/10.18632/aging.100577 23934686Platelet-derivedgrowthfactorBinducessenescenceandtransformationinnormalhumanfibroblasts.!3765581!23934686     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+(Albany+NY) 2013 ; 5 (7): 531-8 Nephropedia Template TP {{tp|p=23934686|t=2013. Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts |pdf=|usr=}}{{23934686}} gab.com Text Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts JO: Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=23934686 #FOAvip Normal cells enter a senescent state upon aberrant oncogenic signals and this response inhibits tumor initiation and progression. It is now well admitted that intracellular and membrane localized oncogenes can illicit oncogene induced senescence. However, the effect of mitogenic growth factor on cellular senescence is so far largely unknown. Here we show that normal human dermal fibroblasts display a complex response to Platelet derived growth factor B (PDGFB) expression. Indeed, PDGFB expression induces, in the same cell population, both senescence and cellular transformation. Remarkably both populations are sustained with passages suggesting that transformed cells eventually enter a senescent state. This senescence state is p53 dependent as inhibiting the p53 pathway blocks the ability of PDGFB to induce senescence and results in strong cellular transformation increase upon PDGFB expression. The relevance of these observations is supported by the fact that human dermatofibrosarcoma protuberans, skin tumors arising from constitutive PDGFB production with little aggressiveness, also display some senescence hallmarks. Together these data support the view that PDGFB, a mitogenic growth factor, has a limited ability to induce senescence. We propose that this low level of senescence might decrease the transforming ability of this factor without totally abolishing it. Twit Text FOAVip Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts ????Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=23934686 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23934686 #FOAvip English Wikipedia <ref>{{Cite pmid|23934686}}</ref> Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts #MMPMID23934686 Vindrieux D; Gras B; Garcia-Belinchon M; Mourah S; Lebbe C; Augert A; Bernard D Aging (Albany NY) 2013[Jul]; 5 (7): 531-8 PMID23934686show ga Normal cells enter a senescent state upon aberrant oncogenic signals and this response inhibits tumor initiation and progression. It is now well admitted that intracellular and membrane localized oncogenes can illicit oncogene induced senescence. However, the effect of mitogenic growth factor on cellular senescence is so far largely unknown. Here we show that normal human dermal fibroblasts display a complex response to Platelet derived growth factor B (PDGFB) expression. Indeed, PDGFB expression induces, in the same cell population, both senescence and cellular transformation. Remarkably both populations are sustained with passages suggesting that transformed cells eventually enter a senescent state. This senescence state is p53 dependent as inhibiting the p53 pathway blocks the ability of PDGFB to induce senescence and results in strong cellular transformation increase upon PDGFB expression. The relevance of these observations is supported by the fact that human dermatofibrosarcoma protuberans, skin tumors arising from constitutive PDGFB production with little aggressiveness, also display some senescence hallmarks. Together these data support the view that PDGFB, a mitogenic growth factor, has a limited ability to induce senescence. We propose that this low level of senescence might decrease the transforming ability of this factor without totally abolishing it. |Animals[MESH] |Cell Line[MESH] |Cellular Senescence/*drug effects/physiology[MESH] |Fibroblasts/*cytology/*drug effects/physiology[MESH] |Gene Expression Regulation/physiology[MESH] |Humans[MESH] |Proto-Oncogene Proteins c-sis/genetics/*metabolism[MESH] |Time Factors[MESH]Platelet-derived growth factor B induces senescence and transformation(epmc).pdf DeepDyve Pubget Overpricing