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10.1016/j.ejca.2013.07.008 http://scihub22266oqcxt.onion/10.1016/j.ejca.2013.07.008 23910495!ä!23910495 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23910495&cmd=llinks): Failed to open stream: HTTP request failed! 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Transient receptor potential melastatin 7 is involved in oestrogen receptor-negative metastatic breast cancer cells migration through its kinase domain |pdf=|usr=}}{{23910495}} gab.com Text Transient receptor potential melastatin 7 is involved in oestrogen receptor-negative metastatic breast cancer cells migration through its kinase domain JO: Eur J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=23910495 #FOAvip Oestrogen receptor negative (ER(-)) invasive ductal carcinoma (IDC) represents a significant clinical challenge and therefore prompts the discovery of novel biomarkers. Transient receptor potential melastatin 7 (TRPM7), a channel protein that also contains a regulatory kinase domain, is overexpressed in IDC and regulates migration. However, the molecular mechanism remains poorly defined. Here, we examined whether TRPM7 regulates migration by its channel function or by its kinase domain. A Magnesium Inhibited Cation current was recorded in two ER(-) highly metastatic breast cancer cell lines. Down-regulation of TRPM7 neither affected Ca(2+)-, nor Mg(2+)-homoeostasis but significantly reduced cell migration via a Ca(2+)-independent pathway. Notably, the overexpression of the truncated kinase domain form of TRPM7 decreased cell migration, while the overexpression of the wild-type form strongly increased it. Concomitantly, TRPM7 silencing reduced the myosin IIA heavy chain phosphorylation. Furthermore, we found higher TRPM7 expression in ER(-) IDC tissues and lymph nodes than in the non-invasive tumoural samples. In conclusion, TRPM7 plays a critical role in breast cancer cell migration through its kinase domain, and our data support the consideration of using TRPM7 as a novel biomarker and a potential therapeutic target in the treatment of human ER(-) IDC. Twit Text FOAVip Transient receptor potential melastatin 7 is involved in oestrogen receptor-negative metastatic breast cancer cells migration through its kinase domain ????Eur J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=23910495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23910495 #FOAvip English Wikipedia <ref>{{Cite pmid|23910495}}</ref> Transient receptor potential melastatin 7 is involved in oestrogen receptor-negative metastatic breast cancer cells migration through its kinase domain #MMPMID23910495 Guilbert A; Gautier M; Dhennin-Duthille I; Rybarczyk P; Sahni J; Sevestre H; Scharenberg AM; Ouadid-Ahidouch H Eur J Cancer 2013[Nov]; 49 (17): 3694-707 PMID23910495show ga Oestrogen receptor negative (ER(-)) invasive ductal carcinoma (IDC) represents a significant clinical challenge and therefore prompts the discovery of novel biomarkers. Transient receptor potential melastatin 7 (TRPM7), a channel protein that also contains a regulatory kinase domain, is overexpressed in IDC and regulates migration. However, the molecular mechanism remains poorly defined. Here, we examined whether TRPM7 regulates migration by its channel function or by its kinase domain. A Magnesium Inhibited Cation current was recorded in two ER(-) highly metastatic breast cancer cell lines. Down-regulation of TRPM7 neither affected Ca(2+)-, nor Mg(2+)-homoeostasis but significantly reduced cell migration via a Ca(2+)-independent pathway. Notably, the overexpression of the truncated kinase domain form of TRPM7 decreased cell migration, while the overexpression of the wild-type form strongly increased it. Concomitantly, TRPM7 silencing reduced the myosin IIA heavy chain phosphorylation. Furthermore, we found higher TRPM7 expression in ER(-) IDC tissues and lymph nodes than in the non-invasive tumoural samples. In conclusion, TRPM7 plays a critical role in breast cancer cell migration through its kinase domain, and our data support the consideration of using TRPM7 as a novel biomarker and a potential therapeutic target in the treatment of human ER(-) IDC. |Breast Neoplasms/*genetics/*pathology[MESH] |Calcium/metabolism[MESH] |Cell Movement/drug effects/*genetics[MESH] |Female[MESH] |Gene Expression Regulation, Neoplastic/drug effects[MESH] |Humans[MESH] |MCF-7 Cells[MESH] |Neoplasm Metastasis[MESH] |Phosphotransferases/chemistry/physiology[MESH] |Protein Structure, Tertiary/physiology[MESH] |RNA, Small Interfering/pharmacology[MESH] |Receptors, Estrogen/metabolism[MESH] |TRPM Cation Channels/antagonists & inhibitors/chemistry/*physiology[MESH]Transient receptor potential melastatin 7 is involved in oestrogen re(epmc).pdf DeepDyve Pubget Overpricing