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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Virology 2013 ; 444 (1-2): 394-403 Nephropedia Template TP
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The severe pathogenicity of alveolar macrophage-depleted ferrets infected with 2009 pandemic H1N1 influenza virus #MMPMID23890814
Kim HM; Kang YM; Ku KB; Park EH; Yum J; Kim JC; Jin SY; Lee JS; Kim HS; Seo SH
Virology 2013[Sep]; 444 (1-2): 394-403 PMID23890814show ga
The in vivo role of alveolar macrophages in the infections with 2009 pandemic H1N1 influenza virus is not as yet known. Ferret study shows that alveolar macrophages are critical for lowering the risk of severe outcomes in 2009 pandemic H1N1 influenza virus infections. Up to 40% of the infected ferrets depleted of alveolar macrophages died, with elevated body temperature and major loss of body weight in contrast to infected ferrets not depleted of alveolar macrophages. The higher viral titers in the lungs were detected in infected ferrets depleted of alveolar macrophages than infected ferrets not depleted of alveolar macrophages 5 days after infection. The inflammatory chemokines were induced at greater levels in the lungs of infected ferrets depleted of alveolar macrophages than in those of infected ferrets not depleted of alveolar macrophages. Our study implies that alveolar macrophages are important for controlling the infections of 2009 pandemic H1N1 influenza virus.
|Animals[MESH]
|Body Temperature[MESH]
|Body Weight[MESH]
|Cytokines/metabolism[MESH]
|Disease Models, Animal[MESH]
|Ferrets[MESH]
|Influenza A Virus, H1N1 Subtype/*immunology/*pathogenicity[MESH]