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10.1007/s00401-013-1154-1 http://scihub22266oqcxt.onion/10.1007/s00401-013-1154-1 23864344/?report=reader!3889169!23864344     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Neuropathol 2013 ; 126 (2): 161-77 Nephropedia Template TP {{tp|p=23864344|t=2013. Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease |pdf=|usr=}}{{23864344}} gab.com Text Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease JO: Acta Neuropathol http://www.kidney.de/pget.php?&tw=1&pmid=23864344 #FOAvip Hippocampal sclerosis of aging (HS-Aging) is a causative factor in a large proportion of elderly dementia cases. The current definition of HS-Aging rests on pathologic criteria: neuronal loss and gliosis in the hippocampal formation that is out of proportion to AD-type pathology. HS-Aging is also strongly associated with TDP-43 pathology. HS-Aging pathology appears to be most prevalent in the oldest-old: autopsy series indicate that 5-30 % of nonagenarians have HS-Aging pathology. Among prior studies, differences in study design have contributed to the study-to-study variability in reported disease prevalence. The presence of HS-Aging pathology correlates with significant cognitive impairment which is often misdiagnosed as AD clinically. The antemortem diagnosis is further confounded by other diseases linked to hippocampal atrophy including frontotemporal lobar degeneration and cerebrovascular pathologies. Recent advances characterizing the neurocognitive profile of HS-Aging patients have begun to provide clues that may help identify living individuals with HS-Aging pathology. Structural brain imaging studies of research subjects followed to autopsy reveal hippocampal atrophy that is substantially greater in people with eventual HS-Aging pathology, compared to those with AD pathology alone. Data are presented from individuals who were followed with neurocognitive and neuroradiologic measurements, followed by neuropathologic evaluation at the University of Kentucky. Finally, we discuss factors that are hypothesized to cause or modify the disease. We conclude that the published literature on HS-Aging provides strong evidence of an important and under-appreciated brain disease of aging. Unfortunately, there is no therapy or preventive strategy currently available. Twit Text FOAVip Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease ????Acta Neuropathol http://www.kidney.de/pget.php?&tw=1&pmid=23864344 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23864344 #FOAvip English Wikipedia <ref>{{Cite pmid|23864344}}</ref> Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease #MMPMID23864344 Nelson PT; Smith CD; Abner EL; Wilfred BJ; Wang WX; Neltner JH; Baker M; Fardo DW; Kryscio RJ; Scheff SW; Jicha GA; Jellinger KA; Van Eldik LJ; Schmitt FA Acta Neuropathol 2013[Aug]; 126 (2): 161-77 PMID23864344show ga Hippocampal sclerosis of aging (HS-Aging) is a causative factor in a large proportion of elderly dementia cases. The current definition of HS-Aging rests on pathologic criteria: neuronal loss and gliosis in the hippocampal formation that is out of proportion to AD-type pathology. HS-Aging is also strongly associated with TDP-43 pathology. HS-Aging pathology appears to be most prevalent in the oldest-old: autopsy series indicate that 5-30 % of nonagenarians have HS-Aging pathology. Among prior studies, differences in study design have contributed to the study-to-study variability in reported disease prevalence. The presence of HS-Aging pathology correlates with significant cognitive impairment which is often misdiagnosed as AD clinically. The antemortem diagnosis is further confounded by other diseases linked to hippocampal atrophy including frontotemporal lobar degeneration and cerebrovascular pathologies. Recent advances characterizing the neurocognitive profile of HS-Aging patients have begun to provide clues that may help identify living individuals with HS-Aging pathology. Structural brain imaging studies of research subjects followed to autopsy reveal hippocampal atrophy that is substantially greater in people with eventual HS-Aging pathology, compared to those with AD pathology alone. Data are presented from individuals who were followed with neurocognitive and neuroradiologic measurements, followed by neuropathologic evaluation at the University of Kentucky. Finally, we discuss factors that are hypothesized to cause or modify the disease. We conclude that the published literature on HS-Aging provides strong evidence of an important and under-appreciated brain disease of aging. Unfortunately, there is no therapy or preventive strategy currently available. |Aged[MESH] |Aging/*pathology[MESH] |Brain Diseases/*epidemiology/*pathology[MESH] |Hippocampus/*pathology[MESH] |Humans[MESH] |Morbidity[MESH] |Prevalence[MESH]Hippocampal sclerosis of aging, a prevalent and high-morbidity brain d(epmc).pdf DeepDyve Pubget Overpricing