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10.1208/s12248-013-9510-6

http://scihub22266oqcxt.onion/10.1208/s12248-013-9510-6
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23856740ImmunogenicityofSubcutaneouslyAdministeredTherapeuticProteins?aMechanisticPerspective.!3787214!23856740
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suck abstract from ncbi


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pmid23856740      AAPS+J 2013 ; 15 (4): 897-900
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  • Immunogenicity of subcutaneously administered therapeutic proteins--a mechanistic perspective #MMPMID23856740
  • Fathallah AM; Bankert RB; Balu-Iyer SV
  • AAPS J 2013[Oct]; 15 (4): 897-900 PMID23856740show ga
  • The administration of therapeutic proteins via the subcutaneous route (sc) is desired for compliance and convenience, but could be challenging due to perceived immunogenic potential or unwanted immune responses. There are clinical and preclinical data supporting as well as refuting the generalized notion that sc is more immunogenic. We provide a mechanistic perspective of immunogenicity of therapeutic proteins administered via the sc route and discuss strategies and opportunities for novel therapeutic approaches to mitigate immunogenicity.
  • |Animals[MESH]
  • |Antigen Presentation/drug effects/*physiology[MESH]
  • |Humans[MESH]
  • |Immunogenetic Phenomena/drug effects/*physiology[MESH]
  • |Immunosuppressive Agents/administration & dosage/immunology/metabolism[MESH]
  • |Injections, Subcutaneous[MESH]
  • |Proto-Oncogene Proteins/administration & dosage/immunology/metabolism[MESH]


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