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10.4161/chan.25292 http://scihub22266oqcxt.onion/10.4161/chan.25292 23807116!3913763!23807116     free     free     free       Channels+(Austin) 2013 ; 7 (5): 402-14 Nephropedia Template TP {{tp|p=23807116|t=2013. Molecular pharmacology of store-operated CRAC channels |pdf=|usr=}}{{23807116}} gab.com Text Molecular pharmacology of store-operated CRAC channels JO: Channels (Austin) http://www.kidney.de/pget.php?&tw=1&pmid=23807116 #FOAvip Calcium influx through store-operated Ca(2+) release-activated Ca(2+) channels (CRAC channels) is a well-defined mechanism of generating cellular Ca(2+) elevations that regulates many functions including gene expression, exocytosis and cell proliferation. The identifications of the ER Ca(2+) sensing proteins, STIM1-2 and the CRAC channel proteins, Orai1-3, have led to improved understanding of the physiological roles and the activation mechanism of CRAC channels. Defects in CRAC channel function are associated with serious human diseases such as immunodeficiency and auto-immunity. In this review, we discuss several pharmacological modulators of CRAC channels, focusing specifically on the molecular mechanism of drug action and their utility in illuminating the mechanism of CRAC channel operation and their physiological roles in different cells. Twit Text FOAVip Molecular pharmacology of store-operated CRAC channels ????Channels (Austin) http://www.kidney.de/pget.php?&tw=1&pmid=23807116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23807116 #FOAvip English Wikipedia <ref>{{Cite pmid|23807116}}</ref> Molecular pharmacology of store-operated CRAC channels #MMPMID23807116 Jairaman A; Prakriya M Channels (Austin) 2013[Sep]; 7 (5): 402-14 PMID23807116show ga Calcium influx through store-operated Ca(2+) release-activated Ca(2+) channels (CRAC channels) is a well-defined mechanism of generating cellular Ca(2+) elevations that regulates many functions including gene expression, exocytosis and cell proliferation. The identifications of the ER Ca(2+) sensing proteins, STIM1-2 and the CRAC channel proteins, Orai1-3, have led to improved understanding of the physiological roles and the activation mechanism of CRAC channels. Defects in CRAC channel function are associated with serious human diseases such as immunodeficiency and auto-immunity. In this review, we discuss several pharmacological modulators of CRAC channels, focusing specifically on the molecular mechanism of drug action and their utility in illuminating the mechanism of CRAC channel operation and their physiological roles in different cells. |Animals[MESH] |Calcium Channel Blockers/*pharmacology[MESH] |Calcium Channels/chemistry/*metabolism[MESH] |Calcium Signaling/drug effects[MESH] |Endoplasmic Reticulum/metabolism[MESH] |Humans[MESH] |Membrane Proteins/chemistry/metabolism[MESH] |Neoplasm Proteins/chemistry/metabolism[MESH] |Protein Conformation[MESH]Molecular pharmacology of store-operated CRAC channels (epmc).pdf DeepDyve Pubget Overpricing