Immune effects of 5-fluorouracil: Ambivalence matters #MMPMID23802066
Ghiringhelli F; Bruchard M; Apetoh L
Oncoimmunology 2013[Mar]; 2 (3): e23139 PMID23802066show ga
Cytotoxic anticancer drugs can promote antitumor immune responses. The anticancer activity of 5-fluorouracil (5FU) relies on the restoration of T-cell immunity following the elimination of myeloid-derived suppressor cells (MDSCs). We have recently discovered that the 5FU-driven activation of the NLRP3 inflammasome in MDSCs promotes tumor angiogenesis by eliciting T(H)17 responses that compromise anticancer immunity. This underscores the need to combine 5-FU with NLRP3 inhibitors to prevent tumor progression.