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10.1158/0008-5472.CAN-13-0362 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-13-0362 23801748/?report=reader!3766408!23801748     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2013 ; 73 (17): 5416-25 Nephropedia Template TP {{tp|p=23801748|t=2013. FOXL1, a novel candidate tumor suppressor, inhibits tumor aggressiveness and predicts outcome in human pancreatic cancer |pdf=|usr=}}{{23801748}} gab.com Text FOXL1, a novel candidate tumor suppressor, inhibits tumor aggressiveness and predicts outcome in human pancreatic cancer JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=23801748 #FOAvip The forkhead box L1 (FOXL1) transcription factor regulates epithelial proliferation and development of gastrointestinal tract and has been implicated in gastrointestinal tumorigenesis in mouse models. However, the role of FOXL1 in pancreatic cancer development and progression remains to be elucidated. Here, we report that higher expression of FOXL1 is significantly associated with better clinical outcome in human pancreatic ductal adenocarcinoma (PDAC). A lower FOXL1 expression is correlated with metastasis and advanced pathologic stage of pancreatic cancer. Mechanistic analyses showed that overexpression of FOXL1 induces apoptosis and inhibits proliferation and invasion in pancreatic cancer cells, whereas silencing of FOXL1 by siRNA inhibits apoptosis and enhances tumor cell growth and invasion. Furthermore, FOXL1 overexpression significantly suppressed the growth of tumor xenografts in nude mice. FOXL1 promoted apoptosis partly through the induction of TNF-related apoptosis-inducing ligand (TRAIL) in pancreatic cancer cells. In addition, FOXL1 suppressed the transcription of zinc finger E-box-binding homeobox 1 (ZEB1), an activator of epithelial-mesenchymal transition, and the negative regulation of ZEB1 contributed to the inhibitory effect of FOXL1 on tumor cell invasion. Taken together, our findings suggest that FOXL1 expression is a candidate predictor of clinical outcome in patients with resected PDAC and it plays an inhibitory role in pancreatic tumor progression. Twit Text FOAVip FOXL1, a novel candidate tumor suppressor, inhibits tumor aggressiveness and predicts outcome in human pancreatic cancer ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=23801748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23801748 #FOAvip English Wikipedia <ref>{{Cite pmid|23801748}}</ref> FOXL1, a novel candidate tumor suppressor, inhibits tumor aggressiveness and predicts outcome in human pancreatic cancer #MMPMID23801748 Zhang G; He P; Gaedcke J; Ghadimi BM; Ried T; Yfantis HG; Lee DH; Hanna N; Alexander HR; Hussain SP Cancer Res 2013[Sep]; 73 (17): 5416-25 PMID23801748show ga The forkhead box L1 (FOXL1) transcription factor regulates epithelial proliferation and development of gastrointestinal tract and has been implicated in gastrointestinal tumorigenesis in mouse models. However, the role of FOXL1 in pancreatic cancer development and progression remains to be elucidated. Here, we report that higher expression of FOXL1 is significantly associated with better clinical outcome in human pancreatic ductal adenocarcinoma (PDAC). A lower FOXL1 expression is correlated with metastasis and advanced pathologic stage of pancreatic cancer. Mechanistic analyses showed that overexpression of FOXL1 induces apoptosis and inhibits proliferation and invasion in pancreatic cancer cells, whereas silencing of FOXL1 by siRNA inhibits apoptosis and enhances tumor cell growth and invasion. Furthermore, FOXL1 overexpression significantly suppressed the growth of tumor xenografts in nude mice. FOXL1 promoted apoptosis partly through the induction of TNF-related apoptosis-inducing ligand (TRAIL) in pancreatic cancer cells. In addition, FOXL1 suppressed the transcription of zinc finger E-box-binding homeobox 1 (ZEB1), an activator of epithelial-mesenchymal transition, and the negative regulation of ZEB1 contributed to the inhibitory effect of FOXL1 on tumor cell invasion. Taken together, our findings suggest that FOXL1 expression is a candidate predictor of clinical outcome in patients with resected PDAC and it plays an inhibitory role in pancreatic tumor progression. |*Apoptosis[MESH] |*Cell Movement[MESH] |*Gene Expression Regulation, Neoplastic[MESH] |Animals[MESH] |Blotting, Western[MESH] |Carcinoma, Pancreatic Ductal/*mortality/prevention & control/secondary[MESH] |Cell Proliferation[MESH] |Chromatin Immunoprecipitation[MESH] |Epithelial-Mesenchymal Transition[MESH] |Forkhead Transcription Factors/genetics/*metabolism[MESH] |Homeodomain Proteins/genetics/metabolism[MESH] |Humans[MESH] |Immunoenzyme Techniques[MESH] |Luciferases/metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Nude[MESH] |Neoplasm Grading[MESH] |Neoplasm Invasiveness[MESH] |Neoplasm Staging[MESH] |Pancreatic Neoplasms/*mortality/pathology/prevention & control[MESH] |Promoter Regions, Genetic/genetics[MESH] |RNA, Messenger/genetics[MESH] |Real-Time Polymerase Chain Reaction[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |TNF-Related Apoptosis-Inducing Ligand/genetics/metabolism[MESH] |Transcription Factors/genetics/metabolism[MESH] |Tumor Cells, Cultured[MESH]FOXL1, a novel candidate tumor suppressor, inhibits tumor aggressivene(epmc).pdf DeepDyve Pubget Overpricing